Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsWith evolving protein therapeutic platforms, newer biopharmaceuticals have been developed as important pharmaceuticals for the treatment of multiple diseases. The safety and efficacy of biological candidates are critical to their clinical success. However, the proteinaceous nature of many drug candidates can lead to an immunogenic response in the patient. As a pioneer company offering immunogenicity assessment services, Creative Biolabs is capable of providing high-quality immunogenicity analysis services of drug candidates for the treatment of autoimmune disease.
It has been reported that a number of factors could influence the immunogenicity of biopharmaceuticals. In terms of the drug, the presence of nonhuman sequences or novel epitopes generated by amino acid substitution designed to enhance stability, or novel epitopes created at the junction of fusion proteins may contribute to the appearance of immunogenicity response. In addition, molecular structure, changes in glycosylation, can also influence the immunogenicity of a biopharmaceutical. Once the immune system is activated, the efficacy of the biotherapeutic declines as the system attempts to clear the antigen. The immune response itself affects product safety as cytokine release can be toxic. For biotherapeutic development, avoiding this response is vital for success.
Fig.1 Evolution of immunogenicity assays for biopharmaceuticals and assessment of anti-adalimumab antibodies. (Pineda, 2016)
Animal testing has been used in an effort to assess the potential immunogenicity of biotherapeutic and protein candidates. Even though helpful to researchers, it is often not a good indicator of what the human immune response will be to the biological candidate. Currently, in silico and in vitro assays are the most widely used methods to assess potential immunogenicity of biotherapeutics. Based on sequence information and structural bioinformatics, in silico assay provides a predictive tool to help determine the likelihood of peptide/HLA binding, a condition necessary for T cell activation. While, in vitro approach utilizes a high throughput, multi-parameter approach to analyze T and B cell responses to the drug candidate. At Creative Biolabs, we offer a full package of assays for potential immunogenicity prediction, which including but not limited to Flow Cytometry, ELISPOT, and ELISA.
Creative Biolabs is committed to offering tailor-designed immunogenicity assessment services to meet our global customers’ needs in a fast, reliable and affordable way. If you are interested in our service to support your development program, please contact us by sending us your detailed request to e-mail. Our scientists will get in touch with you as soon as possible.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
