Magic™ Membrane Protein Human CCR5 (C-C motif chemokine receptor 5) (CAT#: MP0009F)

Datasheet

CCR5 is a receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. CCR5 is G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells. It also serves as the main coreceptor for the entry of R5 strains of human immunodeficiency virus (HIV-1, HIV-2).

Product Specifications

Host Species
Human

Target Protein
CCR5

Protein Length
Full Length

Protein Class
Receptor

Molecular Weight
40 kDa

Sequence
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Product Description

Activity
To be tested

Application
Screening & display technologies

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>50% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
CCR5

Full Name
C-C motif chemokine receptor 5

Introduction
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.

Alternative Names
CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5

Gene ID
1234

UniProt ID
P51681

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Q&As

What are the roles of CCR5 in cancer?

CCR5 induces the homing of cancer cells to metastases, enhances the pro-inflammatory pro-metastatic immune phenotype, and enhances DNA repair, providing abnormal cell survival and resistance to DNA damaging agents.
2022-12-15

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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