Mice are often used to study cancer. Mouse tumor models are one of the commonly used animal models. Establishing an ideal animal model for tumors is of great significance for studying the pathogenesis, treatment, and prevention of tumors. The first animal model for cancer research was the rabbit model, and since then scientists have used multiple models including cell lines and genetically engineered mice to mimic human cancer. A humanized mouse model refers to a mouse model with a functional human gene, cell or tissue that is commonly used as a living replacement model for in vivo studies of human disease. At present, the humanized mouse model has become an important preclinical animal experimental model for studying human diseases. Creative Biolabs provides comprehensive screening models and the establishment of immunologic analysis in a humanized mouse model.
In mouse biological systems, especially the immune system, which is not completely consistent with humans, there are many differences in the innate immune molecules. For example, mice lack functional TLR10, while TLR11, TLR12, and TLR13, but not in the human body. Many human pathogenic factors and drugs are germline-specific, and the immune response characteristics and pathogenic processes caused by certain pathogens are only directed at human cells and are often not infectious pathogens in mice. Due to the existence of these problems and factors, the mouse model is limited to become a reliable and effective tool for truly revealing the research of human biological systems. Therefore, the establishment of an effective humanized mouse model will play an increasingly important role in the study of human-specific infection pathogens, cancer biology and preclinical models of immunotherapy.
Fig.1 Humanized mouse models. (Allen, 2019)
The demand for humanized mice as a translational medical model, including biological research in regenerative medicine, transplantation, and immunology, is also increasing. Creative Biolabs owns rich modeling experience and experimental techniques. Please contact us as soon as possible and we will be happy to help you.
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