Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CD151 molecule (Raph blood group) (CD151) is a four pass transmembrane tetraspanin protein encoded by CD151 gene. This protein localizes to plasma membrane across multiple cell populations. CD151 contains four transmembrane helices, one large extracellular loop, one small extracellular loop plus short cytoplasmic N terminal and C terminal segments. Transmembrane helices assemble inside lipid bilayer, while loop regions are exposed toward extracellular space and short termini reside in cytoplasm. Newly synthesized CD151 folds within endoplasmic reticulum compartments. Conserved cysteine residues inside large extracellular loop support disulfide bond formation required for correct extracellular domain conformation. CD151 can assemble with other membrane partner proteins during secretory trafficking before reaching cell surface. Many cell types express CD151 at detectable levels. Misfolded polypeptide fails to complete secretory transport and gets eliminated by intracellular quality control systems. Protein abundance varies among cell types according to requirement for plasma membrane multi protein complex assembly.
CD151 acts as a membrane embedded scaffold that organizes multi molecular assemblies at plasma membrane. Its transmembrane regions mediate physical association with diverse transmembrane partner proteins including integrin subunits. These intermolecular contacts drive formation of tetraspanin enriched membrane microdomains. Short cytoplasmic termini provide docking surfaces for cytosolic effector molecules. CD151 does not possess intrinsic catalytic or ligand binding activity. Other tetraspanin family members share four pass transmembrane topology but cannot fully reproduce the specific partner interaction profile of CD151. Variation in CD151 abundance changes capacity to assemble these specialized membrane microdomains and alters availability of co assembled partner complexes at cell surface. Mutation within extracellular loop can disturb binding toward surface exposed partner domains. Alteration of transmembrane helices disrupts packing and complex formation with other membrane resident proteins, while changes to cytoplasmic terminal segments impair recruitment of cytosolic binding partners.
Fig. 1 Conserved topology of tetraspanin family protein. Four transmembrane helices separate short cytoplasmic termini, small extracellular loop ECL1 and disulfide‑bonded large extracellular loop ECL2.1
The biological functions of CD151 are focused on tetraspanin enriched membrane microdomain assembly, transmembrane partner protein recruitment and cytoplasmic effector molecule docking:
Creative Biolabs offers purified CD151 membrane samples via standardized preparation workflows, including full length CD151 constructs and isolated extracellular loop variants. Isolated extracellular loop fragments may not support complete transmembrane partner co assembly and microdomain formation related behaviours, while full length constructs may be suited for tetraspanin membrane scaffold associated research. All samples receive routine quality screening, and functional relevant observation may only be carried out with full length samples under simulated membrane environments. All sample batches follow unified processing standards to maintain consistent structural features for comparative laboratory analysis across separate test groups.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides adjustable CD151 expression cell models with varied expression levels, applicable to four pass tetraspanin membrane protein structural characteristic observation and tetraspanin microdomain organization related research. Sample evaluation includes sustained target expression detection and preliminary intermolecular interaction associated observation, which can support comparative analysis of scaffold associated behaviours under different expression statuses. These cell systems can be matched with diverse laboratory analysis schemes to observe changes of membrane complex assembly efficiency under different target expression abundances.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
Antibody reagents targeting CD151 are generated via mature protein preparation workflows, compatible with multiple routine laboratory detection methods for cellular localization profiling and molecular complex identification, to support systematic analysis of CD151 distribution and tetraspanin associated molecular complexes across diverse laboratory research setups. The antibody series can cooperate with other common laboratory detection reagents to complete multi dimensional observation of target distribution inside tissue samples.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CD151 research:
CD151 may function as tetraspanin membrane scaffold protein and participate in tetraspanin enriched microdomain assembly plus transmembrane partner protein recruitment.
CD151 expression status may influence plasma membrane multi protein complex organization, serving as a major regulatory mediator of tetraspanin associated biological processes.
No, all CD151 related products and services are strictly for research use only, not intended for clinical related operations. All material designs and functional tests are only optimized for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full length CD151 membrane protein, target specific recombinant antibodies and adjustable expression cell research models, supporting tetraspanin membrane complex and cell interaction research.
Laboratory observation schemes may include tetraspanin partner protein interaction related tests to analyse scaffold associated behaviours under simulated cellular environments.
