Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CD160 molecule (CD160) is a glycosylphosphatidylinositol-linked immune surface receptor encoded by the CD160 gene, belonging to immunoglobulin variable domain receptor family and acting as a dual modulator of lymphocyte cytotoxic effector function and vascular endothelial immune signaling. CD160 is selectively enriched on innate cytotoxic lymphocyte populations and vascular endothelial monolayers, with evolutionarily conserved extracellular immunoglobulin ligand-binding domains across species, serving as an essential modulator for MHC-independent target cell recognition, cytokine secretion and endothelial barrier immune regulation. CD160-mediated receptor signaling exerts decisive effects on sustaining balanced cytotoxic lymphocyte activation, limiting excessive vascular inflammatory infiltration and maintaining tissue immune surveillance under physiological conditions. Furthermore, CD160 coordinates downstream signaling cascades governing lymphocyte degranulation, endothelial inflammatory responsiveness and tissue vascular homeostasis to safeguard intact circulatory tissue function. Distinct from other cytotoxic immune receptors with divergent signal output profiles, CD160 carries unique non-redundant duties in coordinating both innate lymphocyte killing activity and vascular immune tolerance, rendering it indispensable for regular tumor immune surveillance, vascular inflammatory control and overall circulatory tissue stability.
CD160 executes biological functions through engagement of conserved extracellular ligands to trigger intracellular signal cascades regulating cytotoxic granule mobilization and cytokine production in innate lymphocytes, while simultaneously modulating endothelial cell inflammatory transcription programs to restrain vascular immune cell adhesion and transmigration. Its conserved immunoglobulin ectodomains mediate ligand crosslinking and signal initiation, enabling precise tuning of lymphocyte cytotoxic potency and vascular inflammatory signal transmission. CD160-dependent signaling sustains systemic circulatory immune equilibrium, covering restrained cytotoxic lymphocyte activation cycles, coordinated endothelial barrier stability and persistent tumor antigen surveillance. CD160 participates in an extensive spectrum of biological processes, such as innate lymphocyte cytotoxicity modulation, vascular endothelial immune regulation, tumor immune surveillance and peripheral tissue inflammatory control. Downregulated or dysfunctional CD160 severely impairs tumor-targeted lymphocyte activity, disturbs vascular immune balance and elevates susceptibility to malignant proliferative lesions and chronic vascular inflammatory disorders. Therefore, CD160 constitutes a pivotal research target for investigating innate lymphocyte immunology, vascular immune physiology and tumor immune escape pathogenic mechanisms.
Fig. 1 GPI-anchored CD160 triggers Syk-PI3K-Akt signaling in CLL B cells; activated Akt blocks intrinsic and extrinsic apoptotic cascades, and cooperates with NF-κB/STAT3 to promote leukemic cell survival and proliferation.1
The biological functions of CD160 are focused on immunoglobulin-domain ligand recognition, innate lymphocyte cytotoxic signal transduction and endothelial inflammatory modulation:
Creative Biolabs offers high-quality CD160 proteins via optimized expression systems, covering full-length CD160 and isolated ligand-binding ectodomain variants. These products retain native spatial conformation and intrinsic ligand-binding biological activity, suitable for immune receptor interaction analysis, lymphocyte effector function studies and small molecule compound screening targeting tumor and vascular inflammatory disorders. All CD160 proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered CD160 stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for innate immune receptor research, lymphocyte cytotoxic phenotype observation and immunomodulatory compound response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
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High-specificity recombinant antibodies targeting CD160 are developed with advanced antibody engineering workflows, without cross-reactivity against other immunoglobulin superfamily surface receptors. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, lymphocyte/endothelial membrane localization detection, receptor-ligand binding interaction assessment and tumor immunology research, enabling precise characterization of CD160 expression patterns, subcellular compartment distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CD160 research:
CD160 is a GPI-linked immune surface receptor that mediates innate lymphocyte cytotoxic signaling and balances vascular endothelial inflammatory immune responses.
CD160 exerts irreplaceable control over anti-tumor innate immunity and vascular barrier homeostasis; functional loss exacerbates malignant progression and vascular inflammatory injury, establishing it as a vital research target.
No, all CD160 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include CD160 proteins, high-specificity recombinant antibodies and custom stable cell lines for innate immunity and tumor immune research.
CD160 proteins undergo functional verification via ligand binding affinity assessment, receptor conformational analysis and signal transduction capacity evaluation.
