Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CD58 molecule is a plasma membrane integral glycosylated ligand encoded by CD58 gene, broadly expressed on hematopoietic and non-hematopoietic cells, including dendritic cells, macrophages, epithelial cells, erythrocytes and endothelial cells, localized exclusively to cell surface lipid bilayers. Distinct from other immunoglobulin superfamily surface molecules, CD58 relies on extracellular glycosylated domains to drive specific binding to lymphocyte CD2 receptors, while simultaneously controlling the delivery of secondary co-stimulatory signals toward effector lymphocyte complexes to initiate adaptive immune signal cascades. Under resting physiological immune states, basal CD58 surface expression sustains normal intercellular immune recognition without triggering excessive inflammatory activation. Upon antigen exposure and cell-cell contact, accumulated CD58-CD2 binding complexes stabilize immune cell junctions by CD58, facilitating lymphocyte proliferation and downstream pro-inflammatory cytokine secretion programs. Unlike broad-spectrum adhesion molecules with general cell anchoring roles, CD58 bears specialized immune co-stimulatory functions that cannot be fully compensated by other surface glycoproteins, linking intercellular ligand-receptor interaction directly to antigen-specific immune activation pathways. Loss of functional CD58 severely blunts CD2-dependent lymphocyte-mediated innate and adaptive immune responses and weakens host anti-pathogen and anti-tumor defense capacity, while sustained overabundant CD58 ligation amplifies chronic inflammatory signaling, establishing CD58 as a core research target for membrane immune glycoprotein biology and lymphocyte regulatory mechanism exploration.
CD58 executes core ligand-binding co-stimulatory function embedded within cell surface lipid bilayers, utilizing conserved extracellular glycosylation structures to power high-affinity recognition of lymphocyte CD2 receptors. Conserved extracellular ligand binding pockets exclusively recognize CD2 ectodomain fragments, separating its ligand spectrum from non-specific adhesion receptors distributed on tissue and immune cell surfaces. CD58-mediated receptor-ligand shuttling bridges antigen presentation machinery and lymphocyte co-stimulatory signal transduction, balancing intercellular adhesion efficiency and antigen-triggered inflammatory signal intensity according to antigen exposure levels. CD58 participates in extensive physiological processes including steady-state immune cell recognition, immunological synapse construction and myeloid-lymphoid cell cross-talk. Deficient CD58 expression disrupts antigen pattern recognition and impairs systemic adaptive immune surveillance. Therefore, CD58 represents a pivotal research target for cell surface immunoglobulin superfamily carrier study and immune modulator screening for research applications.
Fig. 1 Multi-scale illustrations depict CD58–CD2 interactions driving T-cell activation, rosette assembly and layered spatial organization inside mature immunological synapses.1
The biological functions of CD58 are focused on CD2 receptor binding, immunological synapse construction and lymphocyte inflammatory signal control:
Creative Biolabs offers high-quality CD58 proteins through optimized expression systems, including full-length membrane glycoprotein and isolated extracellular ligand-binding domain variants. These products retain native conformational characteristics and CD2-dependent binding biological activity, suitable for cell surface receptor interaction assays and immune modulator screening. All CD58 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CD58 stable cell lines, including overexpression and blank control models. These cell lines are optimized for surface ligand expression profiling and lymphocyte co-stimulatory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CD58 are developed via advanced antibody engineering technologies, with no cross-reactivity with other immunoglobulin superfamily adhesion glycoproteins. These antibodies are validated for plasma membrane subcellular localization detection and multi-tissue immune cell expression profiling, and can be combined with CD2 detection reagents to analyze complete immunological synapse receptor complexes in immune cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CD58 research:
CD58 is a cell surface glycosylated ligand that binds lymphocyte CD2 receptors to assemble immunological synapses and initiate complete lymphocyte immune activation.
CD58 acts as a critical link between antigen-presenting cell adhesion and lymphocyte co-stimulation, governing host anti-infection and inflammatory immune responses.
No, all CD58 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length CD58 membrane glycoproteins, isoform-specific detection antibodies and custom stable cell lines for lymphocyte co-stimulation research.
CD58 proteins are validated via CD2 receptor ligand-binding functional testing.
