Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Interleukin 6 receptor (IL6R, CD126) is a type I transmembrane cytokine alpha subunit encoded by the IL6R gene, expressed on hepatocytes, lymphocytes and myeloid subsets, and also generated as soluble extracellular isoform (sIL6R) via proteolytic cleavage, localized to plasma membrane and interstitial fluid compartments. Distinct from shared gp130 signal subunit, membrane-bound IL6R specifically binds IL-6 with low affinity and heterodimerizes with gp130 to initiate canonical classic signaling; soluble IL6R complexes with circulating IL-6 to engage gp130 on receptor-negative cells for trans-signaling cascadesPMC. Under steady tissue homeostasis, basal IL6R expression maintains mild acute-phase responsiveness without excessive systemic inflammation. Upon infection or autoimmune stimulation, accumulated IL-6–IL6R complexes drive JAK/STAT3 transcriptional programs to boost pro-inflammatory mediator release and cell proliferative signals. Unlike ubiquitous shared cytokine subunits, IL6R carries ligand-specific dual signaling functions that cannot be fully substituted by other interleukin receptors, linking IL-6 capture to both protective and pathological inflammatory pathwaysPMC. Loss of functional IL6R blunts systemic acute-phase response and attenuates autoimmune tissue damage, while excess soluble IL6R amplifies chronic inflammatory and oncogenic progression, establishing IL6R as a core research target for dual-signaling cytokine receptor biology and anti-inflammatory compound screening.
IL6R executes IL-6 capture and signal assembly function embedded within cell surface bilayers or secreted as soluble cofactor, utilizing conserved extracellular immunoglobulin-like domains to selectively bind interleukin 6 ligands. Conserved ligand binding pockets exclusively recognize IL-6, separating its substrate spectrum from other inflammatory interleukins distributed across tissue microenvironments. IL6R-mediated gp130 heterodimerization bridges extracellular cytokine stimulation and intracellular JAK/STAT3 signal transduction, balancing classic tissue-protective and trans-signaling pro-inflammatory response magnitude according to local IL-6 concentrationPMC. IL6R participates in hepatic acute-phase protein synthesis, lymphocyte differentiation and stromal tumor inflammation. Deficient IL6R expression disrupts IL-6 dependent dual signal transmission and impairs systemic stress response capacity. Therefore, IL6R represents a pivotal research target for type I cytokine receptor study and autoimmune disorder screening.
Fig. 1 Schematic comparison of IL-6 classic signaling via membrane-bound IL-6Rα and trans-signaling dependent on soluble sIL-6Rα-gp130 complex.1
The biological functions of IL6R are focused on IL-6 ligand binding, gp130 heterodimer assembly and STAT3 signal control:
Creative Biolabs offers high-quality IL6R proteins through optimized expression systems, including full-length transmembrane IL6R and soluble extracellular domain variants. These products retain native IL-6 binding and gp130 heterodimer assembly biological activity, suitable for dual-signaling receptor interaction assays and inflammatory modulator screening. All IL6R proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered IL6R stable cell lines, including overexpression and blank control models. These cell lines are optimized for dual-signaling cytokine receptor profiling and JAK/STAT3 signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting IL6R are developed via advanced antibody engineering technologies, with no cross-reactivity with other interleukin receptor alpha subunits. These antibodies are validated for both cell membrane and soluble IL6R detection, and can be combined with gp130 detection reagents to analyze complete dual-signaling receptor complexes in inflammatory cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for IL6R research:
IL6R is the IL-6-specific alpha receptor subunit that binds IL-6 and recruits gp130 to trigger classic membrane signaling and soluble trans-signaling via JAK/STAT3 pathways.
IL6R governs two distinct IL-6 signaling axes that balance physiological host defense and pathological autoimmunity/tumor inflammation.
No, all IL6R products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length membrane and soluble IL6R proteins, isoform-specific detection antibodies and custom stable cell lines for IL-6 signaling research.
IL6R proteins are validated via IL-6 ligand binding and gp130 heterodimer assembly functional testing.
