Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Integrin subunit alpha V (ITGAV, αV) is a type I transmembrane integrin alpha subunit encoded by the ITGAV gene, forming heterodimers with multiple beta subunits to recognize RGD-containing extracellular matrix ligands. ITGAV is widely distributed across epithelial, endothelial and mesenchymal cell populations, carrying evolutionarily conserved ligand-binding head domains and cytoplasmic signaling tails across species, serving as an essential modulator for cell-matrix anchoring and migratory signal transduction. Apart from embryonic vascular formation, ITGAV also takes part in wound tissue remodeling and stromal microenvironment reshaping during proliferative lesions, dynamically adjusting cell-matrix binding strength to balance tissue repair and invasive cellular movement, and mediates bidirectional signal exchange between extracellular matrix and intracellular cytoskeletal networks. ITGAV-mediated matrix adhesion exerts decisive effects on coordinating endothelial angiogenic sprouting and mesenchymal migratory movement under developmental and pathological conditions. Furthermore, ITGAV coordinates downstream survival and proliferative signaling cascades upon matrix attachment. Distinct from tissue-restricted integrin alpha chains, ITGAV forms promiscuous heterodimers with β1, β3, β5, β6, β8 subunits to support diverse matrix ligand recognition.
ITGAV executes biological functions via non-covalent heterodimerization with beta integrin subunits to assemble complete RGD-binding receptors that bind fibronectin, vitronectin and other matrix glycoproteins, transmitting bidirectional inside-out and outside-in signals regulating cell adhesion strength and migratory capacity. Its conserved ligand-binding pocket mediates specific RGD motif recognition to tune matrix attachment dynamics. ITGAV participates in embryonic angiogenesis, wound repair and malignant cell invasion. Elevated ITGAV expression amplifies angiogenic and migratory phenotypes in proliferative lesions. Therefore, ITGAV constitutes a pivotal research target for matrix cell biology and tumor angiogenic mechanisms.
Fig. 1 ITGAV (αV) forms heterodimers with β3/β5/β8 subunits to drive core malignant phenotypes of cancer, including TGFβ-induced EMT, ECM invasion, pathological angiogenesis, inflammatory pre-metastatic niche formation, cancer stem cell maintenance, metabolic reprogramming and anoikis resistance during tumor metastasis.1
The biological functions of ITGAV are focused on beta subunit heterodimerization and RGD-containing extracellular matrix ligand binding:
Creative Biolabs offers high-quality ITGAV proteins via optimized expression systems, covering full-length ITGAV and ligand-binding head domain variants. These products retain native heterodimerization and RGD-binding activity, suitable for matrix receptor interaction and anti-angiogenic compound screening. Each protein undergoes multi-step purification to remove misfolded aggregates, with matched neutral storage buffer to maintain ligand binding activity over long-term preservation. All ITGAV proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered ITGAV stable cell lines, including overexpression and gene silencing models. These cell lines are optimized for matrix adhesion and angiogenesis research. Multiple rounds of clonal screening are performed to pick cell strains with steady target expression without oscillation in continuous culture, and each clone is attached with expression detection records for reference. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting ITGAV are developed with advanced antibody engineering workflows, without cross-reactivity against other integrin alpha subunits. These antibodies receive multi-scenario functional validation covering cell surface staining and co-immunoprecipitation tests, formulated with mild preservative-free buffer compatible with most matrix interaction detection experiments. All antibody batches are pre-screened for off-target binding signals before delivery.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for ITGAV research:
ITGAV is an integrin alpha subunit that heterodimerizes with multiple beta subunits to form RGD-binding matrix receptors regulating cell adhesion, migration and angiogenesis.
ITGAV drives pathological angiogenesis and tumor cell invasion; it is a central matrix signaling mediator, establishing it as a vital research target.
No, all ITGAV products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include ITGAV proteins, high-specificity recombinant antibodies and custom stable cell lines for matrix adhesion and angiogenesis research.
ITGAV proteins undergo functional verification via beta subunit heterodimerization and RGD ligand binding capacity evaluation.
