Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
UDP glucuronosyltransferase family 2 member B15 (UGT2B15) is a tissue-specific endoplasmic reticulum membrane transferase encoded by the UGT2B15 gene, belonging to the UDP-glucuronosyltransferase superfamily and acting as the primary effector of endogenous steroid glucuronidation and exogenous xenobiotic metabolic clearance. UGT2B15 concentrates expression within hepatic and steroid-responsive epithelial tissues, with evolutionarily conserved UDP-glucuronic acid binding and substrate recognition domains across species, serving as an essential modulator for steroid hormone inactivation, lipophilic compound solubilization and metabolic waste excretion. UGT2B15-mediated glucuronidation activity exerts decisive effects on sustaining balanced systemic steroid hormone levels, limiting toxic metabolite accumulation and maintaining tissue metabolic detoxification capacity under physiological conditions. Furthermore, UGT2B15 coordinates downstream signaling cascades governing hormone homeostasis, cellular xenobiotic adaptation and hepatic tissue defense to safeguard intact organ physiological function. Distinct from other UGT paralogs with divergent substrate selectivity profiles, UGT2B15 carries unique non-redundant duties in androgen and estrogen steroid metabolism, rendering it indispensable for regular hormone signal attenuation, exogenous compound detoxification and overall hepatic stress resistance.
UGT2B15 executes biological functions through binding UDP-glucuronic acid co-substrates and lipophilic target molecules to trigger glucuronide conjugation, converting hydrophobic steroid and xenobiotic substrates into soluble polar metabolites for subsequent excretion, which maintains balanced systemic hormone concentration and reduces intracellular toxic compound deposition. Its conserved functional domains mediate cofactor anchoring and substrate pocket recognition, enabling precise tuning of metabolic conjugation and hormone signal attenuation. UGT2B15-dependent signaling sustains systemic metabolic equilibrium, covering intact steroid glucuronidation cycles, coordinated hepatic detoxification and persistent hormone homeostasis surveillance. UGT2B15 participates in an extensive spectrum of biological processes, such as endogenous steroid hormone metabolism, xenobiotic biotransformation, hepatic detoxification and hormone-dependent tissue regulation. Aberrant expression or functional impairment of UGT2B15 severely disrupts steroid balance stability, disturbs foreign compound clearance and elevates susceptibility to hormone-associated lesions and hepatic metabolic toxicity. Therefore, UGT2B15 constitutes a pivotal research target for investigating phase II drug metabolism, steroid endocrinology and liver toxicological pathogenic mechanisms.
Fig. 1 Androgen receptor-mediated transcriptional upregulation of UGT2B15 drives DHT glucuronidation and counteracts chemical-induced liver injury.1
The biological functions of UGT2B15 are focused on UDP-glucuronic acid dependent transferase catalysis, steroid hormone glucuronidation and xenobiotic metabolic clearance:
Creative Biolabs offers high-quality UGT2B15 proteins via optimized expression systems, covering full-length UGT2B15 and isolated functional domain variants. These products retain native spatial conformation and intrinsic transferase biological activity, suitable for glucuronidation catalytic activity analysis, enzyme-substrate interaction studies and small molecule compound screening targeting liver metabolic disorders. All UGT2B15 proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered UGT2B15 stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for phase II metabolic research, steroid hormone turnover observation and compound toxic response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
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High-specificity recombinant antibodies targeting UGT2B15 are developed with advanced antibody engineering workflows, without cross-reactivity against other UGT family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, endoplasmic reticulum membrane localization detection, enzyme-substrate binding interaction assessment and liver toxicology research, enabling precise characterization of UGT2B15 expression patterns, subcellular compartment distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for UGT2B15 research:
UGT2B15 is a core ER UDP-glucuronosyltransferase that mediates steroid hormone glucuronidation, lipophilic xenobiotic solubilization and hepatic metabolic detoxification.
UGT2B15 exerts irreplaceable control over systemic steroid balance and exogenous compound clearance; its functional defects trigger hormone dysregulation and hepatic metabolic toxicity, establishing it as a vital research target.
No, all UGT2B15 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include UGT2B15 proteins, high-specificity recombinant antibodies and custom stable cell lines for steroid metabolism and liver toxicology research.
UGT2B15 proteins undergo functional verification via transferase catalytic activity assessment, substrate binding selectivity analysis and conformational stability evaluation.
