Recombinant Anti-KIR Mab

DESCRIPTION	CATALOG #	SIZE	PRICE
Recombinant Human Anti-Human KIR Monoclonal Antibody	HOM-19379	1mg	Please Inquiry

Product Detail

Product Overview: Recombinant humanized antibody expressed in CHO binding to human KIR.

Applications: ELISA, WB, IHC, FCM, IP, IF. Optimal dilutions/concentrations should be determined by the end user.

Storage: Store it under sterile conditions at -20 °C upon receiving. Recommend to pack the antibody into smaller quantities for optimal storage.

Stability: Samples are stable for up to twelve months from date of receipt at - °C and are stable for six months at 4 °C.

Background

Antigen Description: Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface proteins found on important cells of the immune system called natural killer (NK) cells. They regulate the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to detect virally infected cells or tumor cells that have a characteristic low level of Class I MHC on their surface. Most KIRs are inhibitory, meaning that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the ability to activate cells. KIR molecules are highly polymorphic, meaning their gene sequences differ greatly between individuals, so that different individuals possess different arrays/repertoires of KIR genes.

Function: HLA-B specific inhibitory MHC class I receptor activity; receptor activity;

Synonyms: KIR3DL1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; KIR; killer cell immunoglobulin-like receptor 3DL1; AMB11; CD158e1; CD158e1/2; CD158e2; cl 2; cl 11; nkat3; NKB1; NKB1B; NKAT-3; NK-receptor; KIR antigen 3DL1; killer Ig receptor; p70 NK receptor CL-2/CL-11; MHC class I NK cell receptor; CD158 antigen-like family member E; p70 killer cell inhibitory receptor; natural killer-associated transcript 3; HLA-BW4-specific inhibitory NK cell receptor; p70 natural killer cell receptor clones CL-2/CL-11; NKAT3; CD158E1; KIR3DL1/S1; MGC119726; MGC119728; MGC126589; MGC126591;