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MemDX™ Antibody Discovery - Mouse PSMA / FOLH1 (44-752) Membrane Protein, Partial, His- tag (CAT#: MP0794F)

Datasheet
This membrane protein is Mouse PSMA / FOLH1 (44-750). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • PSMA / FOLH1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 81.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ile 44 - Ala 752 (Accession # O35409-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 25 mM MES, 500 mM NaCl, pH6.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • PSMA / FOLH1
  • Full Name
  • folate hydrolase 1
  • Introduction
  • This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
  • Alternative Names
  • mo; GCP; GCP2; mopsm; glutamate carboxypeptidase 2; FGCP; GCPII; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; folylpoly-gamma-glutamate carboxypeptidase; glutamate carboxypeptidase II; mGCP; membrane glutamate carboxypeptidase; prostate-specific membrane antigen homolog; pteroylpoly-gamma-glutamate carboxypeptidase

Case Studies

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