Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Bradykinin receptor B2 |
| Gene Name | BDKRB2 |
| Uniprot | P30411 (Human); P32299 (Mouse) |
| Synonym | B2R; BK2; BK-2; BKR2; BRB2; BK-2 receptor; B2 bradykinin receptor |
| Background | BDKRB2 (also called B2 receptor) is a constitutively expressed bradykinin receptor which mediates the majority of the vascular and metabolic actions of kinins. These B2 receptors are ubiquitously expressed by different cell types, such as vascular endothelial and smooth muscle cells, nonvascular smooth muscle cells of the uterus and intestine, fibroblasts, epithelial cells, various tumor cells, and also on leukocytes and in the central nervous system. The B2 receptors are G protein-coupled, 7-transmembrane-spanning receptors. They signal mainly through Gαq, which stimulates phospholipase C to increase intracellular free calcium. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX373 | NativeExtract™ Human BDKRB2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX4061K | MemDX™ Membrane Protein Human BDKRB2 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0117X | MemDX™ Membrane Protein Human BDKRB2 (Bradykinin receptor B2) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
V***an: Seamless customization for truncated mutants.
04/Jun/2023
F***x: A responsive scientific team optimized buffer conditions swiftly.
12/Dec/2023
BDKRB2 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated BDKRB2 Overexpression for Cardiovascular Dysregulation
Creative Biolabs offers AAV-mediated BDKRB2 overexpression services for cardiovascular dysregulation. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters enable spatially controlled BDKRB2 overexpression, particularly in vascular endothelial cells. Preclinical studies demonstrate that AAV9-driven BDKRB2 delivery restores bradykinin-mediated vasodilation in hypertensive models by enhancing receptor density at the plasma membrane. This approach is pivotal for conditions like diabetic vasculopathy, where receptor downregulation exacerbates endothelial dysfunction. Creative Biolabs' proprietary AAV capsid libraries ensure optimal tropism for cardiac and renal tissues, minimizing off-target effects.
Correction of Pathogenic BDKRB2 Variants in Parkinson's Disease Models
Creative Biolabs offers correction of pathogenic BDKRB2 variants services in parkinson's disease models. Structural analysis of BDKRB2 variants reveals disrupted transmembrane topology linked to aberrant G protein signaling. Homology-directed repair (HDR) templates have been designed to restore the receptor's canonical 7-transmembrane architecture, rescuing ligand-binding capacity in dopaminergic neurons. Creative Biolabs' high-fidelity gene-editing screening platform identifies patient-specific mutations and validates corrective RNAs in iPSC-derived neuronal co-cultures, offering a pathway for genotype-specific therapeutics.
Creative Biolabs offers comprehensive and innovative services to drive the development of BDKRB2 cell therapy. Please for more services.
Engineered Mesenchymal Stem Cells (MSCs) for BDKRB2-Driven Tissue Regeneration
Creative Biolabs offers engineered MSCs development services for BDKRB2-driven tissue regeneration. MSCs transfected with BDKRB2 overexpression cassettes secrete elevated levels of angiogenic factors (e.g., VEGF, NO) in ischemic microenvironments. In myocardial infarction models, these cells enhance perfusion by 40% compared to unmodified controls, attributed to amplified bradykinin-BDKRB2 signaling cascades. Creative Biolabs' lentiviral transduction protocols achieve stable integration without oncogenic risk, ensuring scalable production for clinical applications.
BDKRB2-Specific CAR Macrophages in Inflammatory Modulation
Creative Biolabs offers BDKRB2-specific CAR macrophages development services. CAR macrophages engineered to overexpress BDKRB2 exhibit enhanced phagocytic clearance of fibrin deposits in chronic inflammatory lesions. This strategy leverages the receptor's anti-fibrotic properties, as evidenced by reduced collagen deposition in preclinical pulmonary fibrosis trials. Creative Biolabs' immunofluorescence imaging services validate receptor localization and activity in engineered cells, ensuring functional reproducibility.
Creative Biolabs delivers end-to-end solutions for BDKRB2-focused drug development. to design a tailored strategy for your preclinical or clinical program.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
