• CellRapeutics™ CAR Technology
• CellRapeutics™ TCR Technology
• CAR × TCR Bispecific T Cell Engineering Platform
• Surfarray™ Cell Microarray Technology
  • High-throughput Membrane Protein Array Technology
• T-Scan Platform for T Cell-Specific Epitope Identification
• Animal Model Platform for CAR-T Therapeutic Research
  • Pronuclear Injection-based HIS Mouse Model Platform
• Gamma Delta (γδ) T Cell Platform
• Tetravalent Bispecific (TetraBi) T Cell Engager Platform
• CAR-T Cell Display Platform
• CAR-Stem Cell Platform
• CRISPR-edited CAR Cell Technology
• Stable Packaging Cell Line (PCL) Platform
• Immune Monitoring Platform
• mRNA-based CAR Cell Platform
• Tseeking™ Platform For TCR/Ligand Discovery

CAR-T Cytokine Profile Monitoring Service

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Luminex Assay Service helps researchers to monitor the levels of multiple cytokines in a single sample simultaneously. It can be implemented in various applications that covering pathogen detection, drug discovery, biomarker discovery, vaccine development, and cancer research. In particular, Luminex Assay Service is useful for CAR-T development to monitor cytokine profiles of in vitro and in vivo experiment studies. Equipped with state-of-the-art facilities and the largest immediately available retail analyte selection system, Creative Biolabs is dedicated to providing customized Luminex assays services for our global customers.

What is Luminex Assay?

The Luminex technology is a beads-based immunoassay that offers high-throughput detection of both protein and nucleic acid targets in multiple assay chemistries. Luminex assay, which allows for multiplex detection of up to 100 analytes simultaneously in one sample, can greatly reduce time, labor, and cost as compared to single-reaction-based detection methods.

The Luminex assay has been implemented in a variety of applications that range from transplant medicine, biomarker discovery and validation, pathogen detection, drug discovery, vaccine development, personalized medicine, neurodegeneration, and cancer research.

Luminex Assay Principle

Fig.1 How the Luminex assay works.¹

Based on a suspension array, the platform contains capture moieties that are covalently coupled with dyed microspheres internally, also includes phycoerythrin-labeled antibodies binding to the specific antigen-antibody complex on the bead sets. Then, a Luminex instrument recognizes the response and analyses the difference in both bead sets, to identify the bead area and corresponding assigned analyte. The Luminex Assay system allows covalent coupling and detection of respective different types of molecules or macroparticles.

What can we provide?

Creative Biolabs provides customized Luminex assay service for multiple targets analysis, which allows you to carefully choose compatible targets and build your assay using analytes of optimized choice.

Creative Biolabs focuses on the following targets panels, but not limited to:

Our Advantages

1. Quality-assured: Luminex assay services are performed under strict quality systems. We offer accurate, clearly presented, easy to interpret reports.
2. Availability: able to detect analytes across a large-scale of concentrations reliably.
3. High throughput multiplex analysis.
4. Require less sample volume (<50 µL).
5. Efficiency in terms of time and cost for multiple targets.
6. Flexible sample types choices.

Available samples for detection including human, mouse, and rat samples, which can be serum, plasma, and cell culture media types.

As an experienced customization service provider, Creative Biolabs can provide highly efficient and convenient strategies to satisfy your research demands, please feel free to contact us.

Reference

1. Koudriavtseva, Tatiana, et al. "Coagulation/complement activation and cerebral hypoperfusion in relapsing-remitting multiple sclerosis." Frontiers in Immunology 11 (2020): 548604.