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EXPOLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPOLORE MOREWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPOLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPOLORE MOREUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don’t find the answers you’re looking for, contact us for additional assistance.
EXPOLORE MOREGD2 is known as ganglioside G2 or GRD2, which is used as a target for immunotherapy in patients with malignant melanoma and neuroblastoma. This protein is expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. Therefore, GD2 is associated with human neuroblastoma and melanoma.
Associated Disease
| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | |
| CAR-NK-1-M330-2 | Anti-GD2 scFv h(CD28) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28 | Lentiviral | NK cell | |
| CAR-NK-1-M330-G | Anti-GD2 scFv h(FcεRIγ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-FcεRIγ | Lentiviral | NK cell | |
| CAR-NK-1-M330-Z | Anti-GD2 scFv h(CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD3ζ | Lentiviral | NK cell | |
| CAR-NK-2-M330-2Z | Anti-GD2 scFv h(CD28-CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-CD3ζ | Lentiviral | NK cell | |
| CAR-NK-2-M330-4G | Anti-GD2 scFv h(CD4-FcεRIγ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD4-FcεRIγ | Lentiviral | NK cell | |
| CAR-NK-2-M330-4Z | Anti-GD2 scFv h(CD4-CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD4-CD3ζ | Lentiviral | NK cell | |
| CAR-NK-2-M330-8Z | Anti-GD2 scFv h(CD8-CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD8-CD3ζ | Lentiviral | NK cell | |
| CAR-NK-2-M330-BG | Anti-GD2 scFv h(CD28-FcεRIγ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-FcεRIγ | Lentiviral | NK cell | |
| CAR-NK-2-M330-BZ | Anti-GD2 scFv h(41BB-CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-41BB-CD3ζ | Lentiviral | NK cell | |
| CAR-NK-2-M330-CZ | Anti-GD2 scFv h(b2c-CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-b2c-CD3ζ | Lentiviral | NK cell | |
| CAR-NK-3-M330-2BZ | Anti-GD2 scFv h(CD28-41BB-CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-41BB-CD3ζ | Lentiviral | NK cell | |
| CAR-LC007 | Anti-GD2 (huK666) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | huK666 | Human | scFv-CD28-CD3ζ | Retroviral | T cell | |
| CAR-NK-3-M330-2XZ | Anti-GD2 scFv h(CD28-OX40-CD3ζ) CARNK, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-OX40-CD3ζ | Lentiviral | NK cell | |
| CAR-T-1-M326-2 | Anti-GD2 scFv h(CD28) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28 | Lentiviral | T cell | |
| CAR-T-1-M326-G | Anti-GD2 scFv h(FcεRIγ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-FcεRIγ | Lentiviral | T cell | |
| CAR-T-1-M326-Z | Anti-GD2 scFv h(CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M326-2Z | Anti-GD2 scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M326-4G | Anti-GD2 scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD4-FcεRIγ | Lentiviral | T cell | |
| CAR-T-2-M326-4Z | Anti-GD2 scFv h(CD4-CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD4-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M326-8Z | Anti-GD2 scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD8-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M326-BG | Anti-GD2 scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-FcεRIγ | Lentiviral | T cell | |
| CAR-T-2-M326-BZ | Anti-GD2 scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-T-2-M326-CZ | Anti-GD2 scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-b2c-CD3ζ | Lentiviral | T cell | |
| CAR-T-3-M326-2BZ | Anti-GD2 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-T-3-M326-2XZ | Anti-GD2 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | ch14.18 | Chimeric | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell | |
| CAR-LC380 | Anti-GD2 h(CD28-CD3ζ,iCasp-9) Self-destruct CAR, pCDCAR1 | Human | Mouse | scFv-CD28-CD3ζ | Retroviral | NK cell | ||
| CAR-MZ003 | Anti-GD2 scFv h(DAP10) CAR, pCDCAR1 | Human | Human | scFv-DAP10 | Retroviral | T cell | ||
| CAR-MZ021 | Anti-GD2 scFv h(CD28-OX40-CD3ζ) CAR, pCDCAR1 | Human | Human | scFv-CD28-OX40-CD3ζ | Retroviral | T cell | ||
| CAR-MZ173 | Anti-GD2 (Clone 126) h(CD3ζ) CAR, pCDCAR1 | Human | Clone 126 | Mouse | scFv-CD3ζ | Retroviral | T cell | |
| CAR-MZ174 | Anti-GD2 (Clone 126) h(CD28-CD3ζ) CAR, Pcdcar1 | Human | Clone 126 | Mouse | scFv-CD28-CD3ζ | Retroviral | T cell | |
| CAR-MZ044 | Anti-GD2 (14g2a) h(CD3ζ) CAR, pCDCAR1 | Human | 14g2a | Mouse | scFv-CD3ζ | Retroviral | T cell | |
| CAR-MZ046 | Anti-GD2 (14g2a) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 14g2a | Mouse | scFv-41BB-CD3ζ | Retroviral | T cell | |
| CAR-MZ047 | Anti-GD2 (14g2a) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | 14g2a | Mouse | scFv-CD28-41BB-CD3ζ | Retroviral | T cell | |
| CAR-LC008 | Anti-GD2 (14g2a) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 14g2a | Mouse | scFv-CD28-CD3ζ | Retroviral | T cell | |
| CAR-MZ175 | Anti-GD2 (Clone 126) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Clone 126 | Mouse | scFv-41BB-CD3ζ | Retroviral | T cell | |
| CAR-YF203 | Anti-GD2 (3F8) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | 3F8 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF204 | Anti-GD2 (3F8) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 3F8 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-MZ054 | Anti-GD2 (Dinutuximab) scFv h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Dinutuximab | Human | scFv-41BB-CD3ζ | Lentiviral | T cell | |
| CAR-ZP017 | Anti-GD2 (8TMBBZ.2bg.150A) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 8TMBBZ.2bg.150A | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | |
| CAR-YF205 | Anti-GD2 (h3F8) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | h3F8 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell |
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