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Anti-GD2 h(BBζ) CART, Combined with Trametinib (CARP-LX-082)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Anti-GD2 h(BBζ) CART, Combined with Trametinib represents a CAR Plus system, which can be used in the research of Melanoma. In the system, the transduced CAR lentiviral vector was constructed to express scFv of an anti-GD2 antibody linked to the CD28-CD3ζ signaling domains.The CAR Plus system combined Trametinib to improve the antitumor activity and reduce CRS in adoptive immunotherapy. Creative Biolabs provides customized CAR Plus system design and construction services. Please contact us for more detailed information.

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Details

  • Target
  • GD2
  • Targeting Diseases
  • Melanoma
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric 4-1BB and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Target Species
  • Human
  • Gene Name
  • beta-1,4-N-acetyl-galactosaminyltransferase 1
  • Synonyms
  • GALGT; SPG26; GALNACT; GalNAc-T

Small Molecular Details

  • Small melocular
  • Trametinib
  • Small molecular Background
  • Trametinib is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MAP2K; MAPK/ERK kinase; MEK) 1 and 2, with potential antineoplastic activity. Upon oral administration, trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity serine/threonine and tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth.
  • PubChem CID
  • 11707110
  • Combined molecular Synonyms
  • Trametinib; 871700-17-3; GSK1120212; Mekinist; GSK-1120212; GSK 1120212; Trametinib (GSK1120212); JTP 74057;
  • Molecular Weight
  • 615.4g/mol
  • Images

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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