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Lenti-GD2 CAR (scFv-28BBζ, ch14.18)-VP (VP-CAR-LC11)

The ready-to-use lentiviral particles of Lenti-GD2 CAR (scFv-28BBζ, ch14.18)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (ch14.18)-CD28-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • GD2
  • Expression Cassette
  • scFv (ch14.18)-CD28-41BB-CD3ζ
  • Clone
  • ch14.18
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • Neuroblastoma

Target

  • Introduction
  • GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
  • Alternative Names
  • B4GALNT1; beta-1,4-N-acetyl-galactosaminyl transferase 1; disialoganglioside; GALGT; SPG26; GALNACT; GalNAc-T; scFv; FcεRIγ; Chimeric antigen receptor; NK cell; Retrovirus; CARs; Lentivirus; chimeric NK cell receptors; chimeric immunoreceptors; chimeric antigen receptors; ch14.18

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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