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Lenti-GD2 CAR (scFv-28ζ, 14g2a)-VP (VP-CAR-LC514)

The ready-to-use lentiviral particles of Lenti-GD2 CAR (scFv-28ζ, 14g2a)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (14g2a)-CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • GD2
  • Expression Cassette
  • scFv (14g2a)-CD28-CD3ζ
  • Clone
  • 14g2a
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • Neuroblastoma

Target

  • Introduction
  • GD2 is known as ganglioside G2 or GRD2, which is used as a target for immunotherapy in patients with malignant melanoma and neuroblastoma. This protein is expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. Therefore, GD2 is associated with human neuroblastoma and melanoma.
  • Alternative Names
  • GD2; ganglioside antigen GD2

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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