100 Glycan Microarray

Studies have shown that the mechanism of many proteins depends on the interaction between proteins and carbohydrates, and this interaction shows the importance in cell recognition, cellular signal transduction and other fields. Microarrays of defined glycans represent a high throughput approach to determining the specificity of lectins, or more generally glycan-binding proteins. 100 glycan microarray is a kind of widely cover chip to screen general carbohydrate-protein interactions rapidly. Based on our rich experience and profound background knowledge, Creative Biolabs applies the 100 glycan microassay technology to match your research requirement and accelerate your project completion.

Introduction of 100 Glycan Microarray

The study of the activity and interaction of glycans is important to promote immunological research and show many advantages to understanding the interactions between cells. New technologies such as microarrays for glycan-binding applications enable researchers to reveal new information about the vast and evolving field of glycan science. Creative Biolabs’ 100 Glycan Microarray is used as a general test to help researchers determine binding characteristics of antibodies, proteins, bacteria, cell cultures, or other potential biological samples to an array of 100 glycans representing the range of glycans found glycosylated to cell membranes. Our microarray slides are specially coated to be capable of immobilizing natural glycans with close-ring structure at their free-reducing end. While we offer a series of methods to detect the binding of glycans and proteins including SPRi, Imaging Mass Spectrometry and so on.

Fig.1 Construction and application of natural glycan microarrays. (Park, 2009)

Applications of 100 Glycan Microarray

The Glycan-100 array including 100 widely studied glycan shows enormous potential to discover novel carbohydrate-protein interactions. These glycan targets are often reported in the literature which showed important binding functions. For example, it has been shown that a variety of sialic acid glycosides bind to viruses in a specific manner and are involved in inflammation and infectious diseases. Some galectins participate in apoptosis, cell adhesion and T cell activation inhibition by binding β-galactoside. The oligosaccharides of human milk combine with microorganisms to promote the growth of normal flora and inhibit pathogens in the gastrointestinal tract. This technology can be used in many specific services such as Glycoprotein Structure Analysis, Glycoprotein Quantification, High Throughput Glycan Screening Service, Tumor Glyco-diag Service, and Anti-Glycoprotein Antibody Development.

Creative Biolabs provides commercial array products and customized array services according to your research goals for glycomic analysis. Please contact us for more details.

Reference

1. Park, S.; et al. Fluorescent glycan derivatives: their use for natural glycan microarrays. ACS Chem. Biol. 2009, 4(9), 699-701.

Related Services:

1. 100 N-Glycan Microarray
2. Sialic Acid Microarray
3. Glycosphingolipid Microarray
4. Glycosaminoglycan Microarray
5. Human Milk Oligosaccharide Microarray
6. Glycoprotein Microarray
7. Glycopeptide Microarray