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MemDX™ Human FLAG tagged ADCYAP1R1 HEK293T Cell Line, cAMP assay (CAT#: S01YF-1022-KX620)

Datasheet
This product is a HEK293T stable cell line. It stably expresses FLAG tagged ADCYAP1R1 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • ADCYAP1R1
  • Target Protein Species
  • Human
  • Protein Tag
  • FLAG-tag at N-terminus
  • Host Cell Type
  • HEK293T
  • Target Classification
  • GPCR
  • Target Family
  • Vasoactive Intestinal Peptide
  • Target Research Area
  • CNS Research; Digestive and Renal Research
  • Related Diseases
  • Post-Traumatic Stress Disorder; Accommodative Spasm

Product Properties

  • Assay Types
  • cAMP assay
  • Resistance
  • Puromycin
  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Quantity
  • 2x10⁶ cells
  • Form
  • Frozen cells
  • Culture Medium
  • DMEM, 10% FBS, 1 μg/mL puromycin
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • ADCYAP receptor type I
  • Introduction
  • This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
  • GPCR Signaling Pathway
  • The endogenous ligand is pituitary adenylate cyclase-activating polypeptide (PACAP). Targeted protein activation can cause binding of Gs to Go protein which, in turn, cause an inhibition of adenylate cyclase and then decrease of cAMP concentration. It plays a critical role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep.
  • G coupling
  • Gs & Gq
  • Endogenous Ligand
  • Pituitary adenylate cyclase-activating polypeptide (PACAP)
  • Alternative Names
  • PAC1; PAC1R; PACAPR; PACAPRI;pituitary adenylate cyclase-activating polypeptide type I receptor;PACAP receptor 1;PACAP type I receptor;PACAP-R1;adenylate cyclase activating polypeptide 1 (pituitary) receptor type I;pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop;pituitary adenylate cyclase-activating polypeptide type 1 receptor;PACAP-R-1;PACAP-R1;ADCYAP1R1

Case Studies

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