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MemDX™ Membrane Protein Bacterial BmrA (Multidrug resistance ABC transporter ATP-binding protein/permease BmrA) (CAT#: MP0040F)

The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Bacterial
  • Target Protein
  • BmrA
  • Protein Length
  • Full-length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 64.5 kDa
  • TMD
  • 6
  • Sequence
  • MSSSHHHHHHMPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSLLIPLLTKQLVDGFS
    MSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLRELLWKKLIKLPVSYFDTNASGETVSRV
    TNDTMVVKELITTHISGFITGIISVIGSLTILFIMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDE
    TARFTGLLNQILPEIRLVKASNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIG
    YGGMQVSSGELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQIEN
    AHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYSPTAGTIRLGDEPV
    DTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEKAAEMAYALNFIKELPNQFDTEVG
    ERGIMLSGGQRQRIAIARALLRNPSILMLDEATSSLDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVV
    DADQLLFVEKGEITGRGTHHELMASHGLYRDFAEQQLKMNADLENKAG

Product Description

  • Activity
  • Yes
  • Expression Systems
  • E.coli
  • Tag
  • His-tag (N-terminal)
  • Purification
  • Immobilized Metal Affinity Chromatography
  • Purity
  • >90%
  • Buffer
  • 50mM Tris-Cl pH 8.0, 100 mM NaCl, 0.01% DDM, 10%glycerol

Target

  • Target Protein
  • BmrA
  • Full Name
  • Multidrug resistance ABC transporter ATP-binding protein/permease BmrA
  • Introduction
  • An efflux transporter able to transport Hoechst 33342, ethidium bromide, doxorubicin and a number of other drugs in vitro into inside out vesicles. The endogenous substrate is unknown. It has been suggested that NBD dimerization induced by ATP-binding causes a large conformational change responsible for substrate translocation. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
  • Alternative Names
  • bmrA

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