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MemDX™ Membrane Protein Human BDKRB2 (Bradykinin receptor B2) (CAT#: MP0003F)

Datasheet
The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BDKRB2
  • Protein Length
  • Full Length
  • Protein Class
  • Receptor
  • Molecular Weight
  • 44 kDa
  • TMD
  • 7
  • Sequence
  • MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
    PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
    FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
    IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
    TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
    LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
    IQMENSMGTLRTSISVERQIHKLQDWAGSRQ

Product Description

  • Activity
  • Yes
  • Application
  • Screening & display technologies, Structural biology, Antibody development
  • Expression Systems
  • Cell-free expression system
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >75% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • BDKRB2
  • Full Name
  • Bradykinin receptor B2
  • Introduction
  • This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system.
  • Alternative Names
  • B2R, BK2, BK-2, BKR2, BRB2

Case Studies

Customer reviews and Q&As    

Q&As

Gene structure of bradykinin receptor B2)

A related study showed that the genomic clone of BDKRB2 is intronless. While another demonstrated that the BDKRB2 gene contains 3 exons separated by 2 introns. The first and second exons are non-coding, while the third exon contains the full-length coding region.)
2022-12-03)

Effect of agonists of bradykinin receptor B2)

The potent BDKRB2-selective agonist labradimib (Arg-Pro-Hyp-Gly-Thi-Ser-Pro-Tyr(Me)-psi(CH2NH)-Arg) temporarily increases blood-brain barrier (BBB) permeability in the RG2 rat model of glioma and facilitates the entry of chemotherapeutic agents into the CNS to kill brain tumors.)
2022-12-03)

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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