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MemDX™ mPro Human EDNRA Cell Line (CAT#: S01YF-1122-KX21)

Datasheet
This product is a stable cell line. It stably expresses Human EDNRA to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • EDNRA
  • Target Protein Species
  • Human
  • Target Classification
  • GPCR
  • Target Family
  • Endothelin receptor
  • Target Research Area
  • Cardiovascular Research; CNS Research; Pain and Addiction Research
  • Related Diseases
  • Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura

Product Properties

  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Endothelin receptor type A
  • Introduction
  • This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
  • GPCR Signaling Pathway
  • The endogenous ligand is endothelin-1. Targeted protein activation can cause binding of Gq to G11 protein which, in turn, activate a phosphatidylinositol-calcium second messenger system.
  • G coupling
  • Gq
  • Endogenous Ligand
  • Endothelin-1
  • Alternative Names
  • ETA; ET-A; ETAR; ETRA; MFDA; ETA-R; hET-AR; endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor; EDNRA; Endothelin receptor type A

Case Studies

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