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NativeExtract™ Human ADGRL1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX306)

Datasheet
This product is recombinant Human ADGRL1 protein in native nanodisc form. The synthetic compound we developed can solubilize the ADGRL1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADGRL1
  • Protein Length
  • Full length
  • Molecular Weight
  • 162.7kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ADGRL1
  • Full Name
  • Adhesion G protein-coupled receptor L1
  • Introduction
  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.
  • Alternative Names
  • CL1; LEC2; CIRL1; LPHN1; CIRL-1; calcium-independent alpha-latrotoxin receptor 1; latrophilin-1; lectomedin-2; ADGRL1; Adhesion G protein-coupled receptor L1

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