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NativeExtract™ Human ADRA2C Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX325)

Datasheet
This product is recombinant Human ADRA2C protein in native nanodisc form. The synthetic compound we developed can solubilize the ADRA2C protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADRA2C
  • Protein Length
  • Full length
  • Molecular Weight
  • 49.5kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ADRA2C
  • Full Name
  • Adrenoceptor alpha 2C
  • Introduction
  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
  • Alternative Names
  • ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR; adrenergic, alpha-2C-, receptor; alpha-2 adrenergic receptor subtype C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR; alpha2-AR-C4; ADRA2C; Adrenoceptor alpha 2C

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