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NativeExtract™ Human DRD4 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX281)

This product is recombinant Human DRD4 protein in native nanodisc form. The synthetic compound we developed can solubilize the DRD4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • DRD4
  • Protein Length
  • Full length
  • Molecular Weight
  • 43.9kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • DRD4
  • Full Name
  • Dopamine receptor D4
  • Introduction
  • This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
  • Alternative Names
  • D4DR; D(4) dopamine receptor; D(2C) dopamine receptor; dopamine D4 receptor; seven transmembrane helix receptor; DRD4; Dopamine receptor D4

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