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NativeExtract™ Human GHSR Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX255)

Datasheet
This product is recombinant Human GHSR protein in native nanodisc form. The synthetic compound we developed can solubilize the GHSR protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GHSR
  • Protein Length
  • Full length
  • Molecular Weight
  • 41.3kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GHSR
  • Full Name
  • Growth hormone secretagogue receptor
  • Introduction
  • This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
  • Alternative Names
  • GHDP; growth hormone secretagogue receptor type 1; GH-releasing peptide receptor; GHRP; GHS-R; ghrelin receptor; GHSR; Growth hormone secretagogue receptor

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