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NativeExtract™ Human GRM1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX191)

Datasheet
This product is recombinant Human GRM1 protein in native nanodisc form. The synthetic compound we developed can solubilize the GRM1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRM1
  • Protein Length
  • Full length
  • Molecular Weight
  • 132.4kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GRM1
  • Full Name
  • Glutamate metabotropic receptor 1
  • Introduction
  • This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85; glutamate receptor, metabotropic 1; protein phosphatase 1, regulatory subunit 85; GRM1; Glutamate metabotropic receptor 1

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