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NativeExtract™ Human NTSR2 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX140)

Datasheet
This product is recombinant Human NTSR2 protein in native nanodisc form. The synthetic compound we developed can solubilize the NTSR2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NTSR2
  • Protein Length
  • Full length
  • Molecular Weight
  • 45.4kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • NTSR2
  • Full Name
  • Neurotensin receptor 2
  • Introduction
  • The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
  • Alternative Names
  • NTR2; neurotensin receptor type 2; NT-R-2; levocabastine-sensitive neurotensin receptor; neurotensin receptor, type 2; NTSR2; Neurotensin receptor 2

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