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NativeExtract™ Human OPRL1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX128)

Datasheet
This product is recombinant Human OPRL1 protein in native nanodisc form. The synthetic compound we developed can solubilize the OPRL1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • OPRL1
  • Protein Length
  • Full length
  • Molecular Weight
  • 40.7kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • OPRL1
  • Full Name
  • Opioid related nociceptin receptor 1
  • Introduction
  • The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
  • Alternative Names
  • NOP; OOR; KOR3; NOPr; OPRL; ORL1; KOR-3; NOCIR; nociceptin receptor; kappa-type 3 opioid receptor; kappa3-related opioid receptor; nociceptin/orphanin FQ receptor; opiate receptor-like 1; orphanin FQ receptor; OPRL1; Opioid related nociceptin receptor 1

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