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O'nyong'nyong Virus-like Particles (ONNV VLPs) (CAT#: VLP-022YF)

Datasheet
Recombinant O'nyong'nyong Virus-like Particles (ONNV VLPs) are produced in mammalian HEK293 human cells, assembled with E1, E2 and Capsid proteins. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. ONNV VLPs can be used in the development of ONNV diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Structural Proteins
  • E1, E2 and Capsid proteins
  • Expression Systems
  • HEK293 (please specify if other expression system is needed)
  • Purity
  • >90%
  • Buffer
  • 20mM Tris-HCl pH8.0, 160mM NaCl
  • Form
  • Liquid
  • Alternative Names
  • O'nyong'nyong Virus-like Particles; ONNV VLPs; O'nyong'nyong Virus; ONNV Virus-like Particles; VLPs; Virus-like Particles
  • Storage
  • Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Togaviridae
  • Virus Species
  • O'nyong'nyong virus
  • Virus Overview
  • The ONNV genome is a positive-sense, single-stranded, nonsegmented RNA of ~11.7 kb which replicates exclusively in the cytoplasm of infected cells. Replication of alphavirus RNA occurs at intracellular membranes in infected cells and leads to formation of dsRNA forms called replicative intermediates. The subgenomic (26S) mRNA is translated into a structural polyprotein from which capsid and envelope glycoproteins are produced as cleavage products; the capsid protein has protease activity which results in its autocatalytic cleavage from the nascent structural protein.
  • Virus Structure
  • Enveloped, positive-sense, single-stranded RNA virus
  • Related Disease
  • Polyarthritis, rash and fever.

Case Studies

Customer reviews and Q&As    

Customer Review

ONNV VLP induces a strong immune response)

ONNV VLP is capable of acting as a direct immunogen to induce strong cellular and humoral responses.)
2022-12-21)

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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