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Type 1 Poliovirus Virus-like Particles (PV-1 VLPs) (CAT#: VLP-001YF)

Datasheet
Recombinant Type 1 Poliovirus Virus-like Particles (PV-1 VLPs) are produced in Baculovirus/Insect cell expression system. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. PV-1 VLPs can be used in the development of PV-1 diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Expression Systems
  • Baculovirus/Insect cell expression system (please specify if other expression system is needed)
  • Form
  • Liquid
  • Alternative Names
  • Poliovirus; Type 1 Poliovirus; Type-1 Poliovirus; PV1; PV-1; PV; VLP; Virus-like particle
  • Storage
  • Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Picornaviridae
  • Virus Species
  • Enterovirus C
  • Virus Overview
  • Poliovirus (PV) is the causative agent of polio, which is also known as poliomyelitis. Poliovirus is a serotype of the species Enterovirus C, in the family of Picornaviridae. PV is composed of an RNA genome and a protein capsid. The genome is a single-stranded positive-sense RNA genome that is about 7500 nucleotides long. The viral particle is about 30 nm in diameter with icosahedral symmetry. Because of its short genome and its simple composition-only RNA and a nonenveloped icosahedral protein coat that encapsulates it, poliovirus is widely regarded as the simplest significant virus.
  • Virus Structure
  • Non-enveloped, positive-sense, single-stranded RNA virus
  • Related Disease
  • Polio disease

Case Studies

Customer reviews and Q&As    

Customer Review

Triggers a strong immune response)

Mice immunized with baculovirus vector system-generated PV-1 VLP developed antibodies that had a strong PV neutralization response.)
2022-11-01)

Passed the ELISA kit)

ELISA test results with PV-1 VLP as an antigen have a high correlation and can be used for serological diagnosis.)
2022-11-01)

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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