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MemDX™ Recombinant Full Length Human ADORA2A Protein (Biotinylated Nanodisc, Rho1D4 Tag & FLAG Tag) (CAT#: SYF-0926-CW35)

Recombinant full-length human ADORA2A protein reconstituted in a biotinylated nanodisc membrane-mimetic system for immobilization, binding, detection, and assay development applications; the copolymer is biotinylated while the protein itself remains unmodified.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADORA2A
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 45 kDa
  • Sequence
  • PIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

Product Description

  • Expression Systems
  • Trichoplusia ni insect cells
  • Tag
  • The construct includes an N-terminal FLAG tag and a C-terminal Rho1D4 tag. The copolymer is biotinylated; the protein itself is unmodified.
  • Protein Format
  • Nanodisc
  • Purity
  • The protein purity is greater than 90% as determined by SDS-PAGE.

Target

  • Target Protein
  • ADORA2A
  • Full Name
  • adenosine A2a receptor
  • Introduction
  • Adenosine receptor A2a (ADORA2A) is a full-length human gpcr. Adenosine receptor A2a is a receptor protein, and adenosine is its preferred endogenous agonist. It interacts with G(s) and G(olf), increasing cAMP levels. The adenosine receptor is involved in regulating pain, controlling blood flow in the brain and inflammation, and it has been identified as a target for Parkinson's disease treatment. The surrounding nanodisc copolymer is biotinylated to support direct surface immobilization without modifying the protein itself. The preparation uses 2-step purification.
  • Alternative Names
  • RDC8, ADORA2

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