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NativeExtract™ Recombinant Full Length Human GBRD Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW74)

This product is recombinant Human GBRD protein in native nanodisc form. The synthetic compound we developed can solubilize the GBRD protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GBRD
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 50.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GBRD
  • Full Name
  • Gamma-Aminobutyric Acid Type A Receptor Delta Subunit
  • Introduction
  • Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
  • Alternative Names
  • Gamma-Aminobutyric Acid Type A Receptor Delta Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor, Delta; GABA(A) Receptor Subunit Delta; GABA(A) Receptor, Delta; Gamma-Aminobutyric Acid Receptor Subunit Delta; GABA-A Receptor, Delta Polypeptide; GEFSP5; EIG10; EJM7

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