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NativeExtract™ Recombinant Full Length Human SCNBA Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW155)

Datasheet
This product is recombinant Human SCNBA protein in native nanodisc form. The synthetic compound we developed can solubilize the SCNBA protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCNBA
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 204.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • SCNBA
  • Full Name
  • Sodium Voltage-Gated Channel Alpha Subunit 11
  • Introduction
  • Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • Sodium Voltage-Gated Channel Alpha Subunit 11; Sodium Channel, Voltage-Gated, Type XI, Alpha Polypeptide; Sodium Channel, Voltage-Gated, Type XI, Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.9; Sodium Channel Protein Type XI Subunit Alpha; Peripheral Nerve Sodium Channel 5; Sensory Neuron Sodium Channel 2; SCN12A; PN5; Sodium Channel, Voltage-Gated, Type XII, Alpha Polypeptide; Sodium Channel, Voltage Gated, Type XI Alpha Subunit

Case Studies

Customer reviews and Q&As    

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