Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Apoptosis associated tyrosine kinase (AATK) is an intracellular membrane-associated kinase encoded by AATK gene, predominantly expressed in neuronal tissue and hematopoietic cell subsets, localized to endosomal and cytoplasmic membrane compartments. Distinct from other cytoplasmic kinase paralogs, AATK relies on conserved catalytic kinase domains to mediate targeted substrate phosphorylation, while simultaneously controlling the transmission of growth arrest and apoptotic signaling cascades toward core cell cycle regulators. Under basal physiological conditions, moderate AATK kinase activity sustains balanced cell turnover without triggering widespread programmed cell death. Upon cellular damage or oncogenic stress, elevated AATK expression drives phosphorylation of tumor-suppressive substrates to suppress proliferation and initiate apoptotic clearance of abnormal cells. Unlike housekeeping kinases with broad metabolic roles, AATK bears specialized growth-restrictive and pro-apoptotic functions that cannot be fully compensated by other kinase family members, linking substrate phosphorylation directly to cell cycle arrest and tumor suppressive pathways. Loss of functional AATK kinase activity blunts cellular damage surveillance and accelerates aberrant cell proliferation, while sustained AATK overexpression amplifies apoptotic clearance capacity, establishing AATK as a core research target for kinase signaling and anti-tumor compound screening.
AATK executes core tyrosine kinase catalytic function anchored to intracellular membrane compartments, utilizing conserved ATP-binding pockets to mediate selective phosphorylation of cell cycle and tumor-suppressive substrates. Conserved substrate recognition motifs exclusively target proliferation regulatory factors, separating its substrate spectrum from ubiquitously expressed cytoplasmic kinases. AATK-mediated phosphorylation bridges cellular stress sensing and downstream growth inhibitory signal transduction, balancing proliferative turnover and apoptotic clearance intensity according to cellular damage load. AATK participates in extensive physiological processes including neuronal differentiation, cell cycle suppression and stress-triggered apoptosis. Deficient AATK expression disrupts damage-induced growth arrest and impairs intrinsic tumor suppression capacity. Therefore, AATK represents a pivotal research target for intracellular kinase biology and anti-proliferative modulator screening.
Fig. 1 Intronic miR‑338 encoded inside AATK intron 7 undergoes sequential transcription, splicing and Dicer cleavage; the final mature miRNA loads into RISC to mediate translational repression against host AATK transcripts.1
The biological functions of AATK are focused on substrate phosphorylation, cell cycle suppression and apoptotic pathway modulation:
Creative Biolabs offers high-quality AATK proteins through optimized expression systems, including full-length kinase protein and isolated catalytic domain variants. These products retain native kinase catalytic activity, suitable for substrate binding and anti-proliferative compound screening. All AATK proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered AATK stable cell lines, including overexpression and blank control models. These cell lines are optimized for kinase activity profiling and apoptotic signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting AATK are developed via advanced antibody engineering technologies, with no cross-reactivity with other cytoplasmic tyrosine kinase paralogs. These antibodies are validated for intracellular membrane localization detection and tissue expression profiling, and can be combined with cell cycle detection reagents to analyze complete AATK signaling complexes in stress cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for AATK research:
AATK is a membrane-associated tyrosine kinase that mediates substrate phosphorylation to drive cell cycle arrest and stress-induced apoptosis.
AATK acts as a critical link between cellular stress sensing and tumor suppressive apoptotic signaling, governing abnormal cell clearance.
No, all AATK products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length AATK kinase proteins, isoform-specific detection antibodies and custom stable cell lines for apoptosis research.
AATK proteins are validated via substrate phosphorylation functional testing.
