Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Annexin A2 (ANXA2) is a calcium-binding peripheral membrane scaffold protein encoded by the ANXA2 gene, composed of an N-terminal regulatory tail and four conserved calcium-binding annexin repeat domains, and acts as a calcium-dependent bridging subunit linking membrane phospholipids and extracellular matrix signaling complexes. ANXA2 is widely expressed across endothelial, epithelial and mesenchymal cell populations, serving as a core scaffold mediating membrane-matrix complex assembly and downstream proliferative kinase recruitment upon calcium ion stimulation.
ANXA2 exerts its biological effects through calcium-dependent membrane phospholipid binding and heteromeric co-assembly with partner proteins, a mechanism that stabilizes membrane-matrix interface complexes and modulates intracellular remodeling signal cascade activation efficiency. Unlike integral membrane receptors, ANXA2 cannot independently initiate transmembrane signal transduction and relies on calcium-mediated membrane anchoring to coordinate multiple upstream signaling inputs; it recruits cytoplasmic signal mediators to clustered membrane-matrix complexes, uncoupling extracellular matrix ligand sensing from intracellular proliferative transcription factor activation and sustaining persistent tissue remodeling response signals. This dual regulation modulates the intensity of matrix-triggered cellular remodeling responses after calcium elevation, fine-tuning local cell migration and matrix protease secretion levels, while sustained abnormal ANXA2-mediated membrane scaffolding drives dysregulated extracellular matrix turnover and proliferative vascular lesions. ANXA2 participates in key physiological and pathological processes including calcium-dependent membrane anchoring, matrix protease activation, endothelial tissue remodeling and chronic proliferative vascular disorders. Dysregulation of ANXA2 expression or calcium-binding capacity is closely associated with disordered matrix degradation and impaired vascular tissue homeostasis, making ANXA2 a crucial research target for calcium membrane scaffold signaling, matrix remodeling and vascular proliferative disease research.
Fig. 1 Endothelial membrane ANXA2-p11 heterotetramer recruits tPA and plasminogen to drive fibrinolysis. Src phosphorylation activates ANXA2, while homocysteine, autoantibodies and oscillatory stress suppress its fibrinolytic activity. ANXA2 also regulates vWF secretion and plasmin generation in APL cells.1
The biological functions of ANXA2 are focused on calcium-mediated membrane complex assembly, matrix remodeling signal propagation and vascular tissue balance:
Creative Biolabs offers high-purity ANXA2 proteins through optimized heterologous expression systems, including full-length ANXA2 and isolated calcium-binding annexin repeat domain variants with modified phospholipid binding characteristics. These products retain native conformational characteristics and calcium-dependent membrane complex binding activity, suitable for calcium membrane scaffold research, membrane-matrix complex interaction detection, and small molecule vascular remodeling regulator screening for proliferative vascular disorder research. All ANXA2 proteins undergo strict quality control, including purity analysis and biological activity validation to ensure biological function.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered ANXA2 stable cell lines, including overexpressing and knockdown models in endothelial and mesenchymal cell models. These cell lines are optimized for studying ANXA2-mediated calcium membrane scaffold assembly mechanisms, matrix remodeling signal cascade dynamics, and vascular remodeling regulatory compound sensitivity. Each cell line undergoes stringent validation, including stable expression detection and functional integrity verification.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting ANXA2 are developed via advanced antibody engineering technologies, with no cross-reactivity with other annexin family subunits. These antibodies are validated for multiple applications, including immunofluorescence for ANXA2 membrane peripheral localization, Western blot for expression analysis, and co-immunoprecipitation for ANXA2-calcium-membrane complex research, enabling precise analysis of ANXA2 expression, subcellular localization and functional regulation.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for ANXA2 research:
ANXA2 is a calcium-dependent peripheral membrane scaffold protein that bridges phospholipid bilayers and matrix signaling complexes to modulate matrix protease and migratory signal amplitude, balance endothelial tissue remodeling dynamics, and coordinate extracellular matrix turnover under elevated intracellular calcium conditions.
ANXA2 is a core regulator of calcium-mediated membrane scaffolding and vascular matrix homeostasis, and its dysregulation is associated with excessive matrix proteolysis and chronic proliferative vascular lesions. It is a critical target for annexin calcium scaffold and vascular remodeling disease research.
No, all ANXA2 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include ANXA2 proteins (full-length, calcium-binding repeat domain variants), specific recombinant antibodies, and custom stable endothelial cell lines, supporting calcium scaffold and vascular remodeling research.
ANXA2 proteins are validated by calcium-dependent membrane phospholipid binding assays and matrix remodeling signal regulation verification to ensure native regulatory function in vascular tissue research.
