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BST1

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Background

Bone marrow stromal cell antigen 1 (BST1) is a glycosylated membrane ectoenzyme encoded by the BST1 gene, belonging to ADP-ribosyl cyclase enzyme family and acting as a core regulator of bone marrow stromal niche signaling and hematopoietic immune cell maturation. BST1 is predominantly expressed in bone marrow stromal fibroblasts, hematopoietic progenitor populations and mature immune cells, with evolutionarily conserved extracellular catalytic cyclase domains across species, serving as an essential modulator for cyclic ADP-ribose generation, intracellular calcium mobilization and stromal niche cytokine secretion. BST1-mediated enzymatic activity exerts decisive effects on sustaining balanced hematopoietic progenitor proliferation, supporting stepwise immune cell differentiation and maintaining intact bone marrow microenvironment stability under physiological conditions. Furthermore, BST1 coordinates downstream signaling cascades governing stromal cell cross-talk, progenitor survival and tissue immune cell trafficking to safeguard steady hematopoietic tissue function. Distinct from other cyclase enzymes with divergent tissue expression patterns, BST1 carries unique non-redundant duties in bone marrow niche signal transduction, rendering it indispensable for regular hematopoietic development, stromal-immune cell communication and overall bone marrow tissue homeostasis.

BST1 executes biological functions through extracellular catalytic conversion of NAD substrates to generate cyclic ADP-ribose signaling molecules, which modulate calcium-dependent transcriptional programs governing progenitor cell survival and differentiation within the bone marrow niche, forming a supportive signaling network for hematopoietic lineage maturation. Its conserved catalytic ectodomains mediate substrate recognition and cyclic nucleotide synthesis, enabling precise tuning of stromal niche signaling intensity and immune progenitor developmental signal transmission. BST1-dependent signaling sustains systemic hematopoietic equilibrium, covering intact cyclic nucleotide signaling cycles, coordinated stromal-hematopoietic cell interaction and persistent progenitor pool maintenance. BST1 participates in an extensive spectrum of biological processes, such as ADP-ribosyl cyclase catalytic metabolism, bone marrow stromal niche regulation, hematopoietic immune cell differentiation and progenitor cell survival control. Suppressed or dysfunctional BST1 severely disrupts stromal niche supportive signaling, disturbs immune progenitor maturation balance and elevates susceptibility to hematopoietic developmental defects and bone marrow inflammatory lesions. Therefore, BST1 constitutes a pivotal research target for investigating stromal niche biology, hematopoietic developmental physiology and bone marrow disorder pathogenic mechanisms.

Fig. 1 CD157 (BST1)-integrin signaling axis controlling cell survival and mitochondrial apoptosis via AKT-mTOR and Mcl-1 regulatory networks. (OA Literature)Fig. 1 Membrane CD157 (BST1) interacts with integrins to activate ERK and AKT pathways. AKT inhibits GSK-3β to stabilize Mcl-1 and block mitochondrial apoptosis, while triggering mTORC1 cascade to maintain cell survival. Mcl-1 inhibitor counteracts CD157-mediated anti-apoptotic effects.1

BST1 Protein Function: Core Roles in Cyclic Nucleotide Signaling and Bone Marrow Niche Homeostasis

The biological functions of BST1 are focused on extracellular ADP-ribosyl cyclase catalysis, cyclic nucleotide signal generation and hematopoietic progenitor regulation:

  • Cyclic ADP-Ribose Synthesis: Catalyzes extracellular NAD conversion to produce secondary calcium-mobilizing signaling mediators.
  • Bone Marrow Niche Signaling: Mediates paracrine communication between stromal cells and hematopoietic progenitors to sustain developmental support.
  • Immune Cell Maturation Modulation: Regulates calcium-dependent transcriptional programs driving stepwise differentiation of immune progenitor lineages.
  • Stromal Tissue Homeostasis: Maintains balanced cytokine secretion from bone marrow stromal cells to stabilize local hematopoietic microenvironment.
  • Disease Relevance: Indispensable for intact hematopoietic progenitor development and stromal niche function; impaired activity leads to disrupted immune cell maturation and bone marrow dysfunction.

BST1 Protein Product

Creative Biolabs offers high-quality BST1 proteins via optimized expression systems, covering full-length BST1 and isolated catalytic cyclase domain variants. These products retain native spatial conformation and intrinsic ADP-ribosyl cyclase biological activity, suitable for ectoenzyme catalytic activity analysis, stromal cell interaction studies and small molecule compound screening targeting hematopoietic developmental disorders. All BST1 proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.

BST1 Membrane Protein Product

Not finding the membrane protein product you need? Contact us to start your one-stop custom service!

BST1 Stable Cell Line Product

Creative Biolabs provides custom engineered BST1 stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for bone marrow niche research, hematopoietic progenitor differentiation observation and stromal regulatory compound response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.

BST1 Stable Cell Line Product

Not finding the stable cell line product you need? Contact us to start your one-stop custom service!

BST1 Recombinant Antibody Product

High-specificity recombinant antibodies targeting BST1 are developed with advanced antibody engineering workflows, without cross-reactivity against other ADP-ribosyl cyclase family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, stromal cell membrane localization detection, enzyme-substrate binding interaction assessment and hematopoietic niche research, enabling precise characterization of BST1 expression patterns, subcellular compartment distribution and functional modulation under physiological and pathological states.

BST1 Recombinant Antibody Product

Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!

Product Features

  • Native Cyclase Catalytic Activity: Preserves endogenous extracellular ADP-ribosyl cyclase capacity and cyclic nucleotide signaling function, supporting accurate stromal niche and hematopoietic developmental research.
  • Ectoenzyme Family Specificity: Validated for stable biological activity and specific stromal cell membrane binding, delivering consistent and repeatable research readouts.
  • Hematopoietic Niche Compatibility: Optimized for cyclic nucleotide signaling analysis, progenitor differentiation detection and stroma-targeted regulatory compound discovery, supplying reliable research tools.
  • Comprehensive Customization Support: Facilitates end-to-end development of customized proteins, antibodies and stable cell lines to address diverse bone marrow stromal and hematology research requirements.

Custom BST1 Research Services

Beyond catalog products, Creative Biolabs offers specialized custom services for BST1 research:

  • Custom BST1 Protein Production: Tailored expression of BST1 sequence variants, epitope-tagged ectoenzymes and domain-truncated constructs for cyclic nucleotide synthesis and stromal niche interaction research.
  • Custom Antibody Development: Generation of BST1-specific antibodies for expression detection, stromal membrane localization profiling, enzyme substrate binding evaluation and functional mechanism exploration.
  • Stable Cell Line Engineering: Custom BST1-modified cell models and bone marrow niche research platforms with standardized functional validation.
  • Functional Assay Development: Design of BST1-mediated cyclic ADP-ribose generation, stromal progenitor communication and hematopoietic developmental homeostasis detection assays.

Frequently Asked Questions (FAQ)

  1. What is the primary function of BST1?

    BST1 is a stromal membrane ADP-ribosyl cyclase that generates cyclic ADP-ribose mediators to regulate bone marrow niche signaling and hematopoietic immune cell differentiation.

  2. Why is BST1 a significant research target?

    BST1 exerts irreplaceable control over stromal-hematopoietic communication and immune progenitor maturation; functional impairment disrupts bone marrow microenvironment balance, establishing it as a vital research target.

  3. Are Creative Biolabs' BST1 products suitable for clinical use?

    No, all BST1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.

  4. What types of BST1 products does Creative Biolabs offer?

    Offerings include BST1 proteins, high-specificity recombinant antibodies and custom stable cell lines for bone marrow stromal and hematopoietic development research.

  5. How are BST1 proteins validated for activity?

    BST1 proteins undergo functional verification via cyclase catalytic activity assessment, substrate binding affinity analysis and extracellular conformational stability evaluation.

Reference
  1. Yakymiv, Yuliya, et al. "CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1." Scientific reports 11.1 (2021): 21230. Under Open Access license CC BY 4.0, without modification. https://doi.org/10.1038/s41598-021-00733-5
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