Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Cell adhesion molecule 1 (CADM1, also known as TSLC1) is a single-pass transmembrane adhesion protein of the immunoglobulin superfamily encoded by the CADM1 gene. It is expressed in epithelial, neural, and Sertoli cells and contributes to intercellular junction organization. Unlike classical adhesion molecules such as E-cadherin, CADM1 mediates both homophilic and heterophilic cell-cell adhesion through its extracellular immunoglobulin-like domains and interacts with intracellular scaffold proteins through its cytoplasmic tail. CADM1 contributes to epithelial integrity and regulation of cell migration, and reduced CADM1 expression, including through promoter hypermethylation, has been associated with tumor progression in several cancer types. CADM1 also participates in neural development and male reproductive function, making it an important research target in IgSF-mediated adhesion and tumor biology.
CADM1 mediates intercellular adhesion through extracellular Ig-like domains and links cell-cell contacts to intracellular scaffold and polarity networks. Its adhesion and signaling functions contribute to epithelial homeostasis, neural development, and tissue organization. Loss or reduced expression of CADM1 has been associated with impaired cell adhesion and enhanced malignant phenotypes in multiple tumor models, although the underlying mechanisms are context dependent. Therefore, CADM1 represents an important research target for IgSF adhesion biology and tumor suppressor-associated mechanisms.
Fig. 1 Structural schematic of CADM1 homotypic cell adhesion complex with cytoplasmic Dlg scaffold coupling and downstream oncogenic MAPK signal suppression.1
The biological functions of full-length transmembrane CADM1 adhesion glycoprotein are fully focused on homotypic cell dimerization and oncogenic MAPK signal inhibition:
Creative Biolabs offers high-quality CADM1 proteins through optimized eukaryotic expression systems, including full-length wild-type CADM1 and isolated Ig ligand-binding domain variants. These products retain native homotypic cell adhesion and scaffold co-binding activity, suitable for tumor metastasis inhibitory screening assays. All CADM1 proteins undergo strict quality control to ensure consistent performance and reliable application across epithelial oncology research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CADM1 stable cell lines, including tumor suppressor overexpression and blank empty vector control models. These cell lines are optimized for Ig adhesion molecule profiling and migratory tumor signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles during long-term epithelial cell culture, and can be widely deployed for anti-metastasis compound screening experiments.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CADM1 are developed via advanced antibody engineering technologies. These antibodies are validated for epithelial junction membrane localization detection and lung tumor tissue expression profiling, and can be combined with Dlg scaffold detection reagents to analyze complete CADM1 polarity complexes in epithelial cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CADM1 research:
CADM1 is an IgSF adhesion molecule that mediates homotypic cell contact and represses proliferative oncogenic signals as a tumor suppressor.
Epigenetic loss of CADM1 is a common driver of epithelial cancer metastasis, a promising anti-metastasis therapeutic target.
No, all CADM1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length CADM1 adhesion glycoproteins, isoform-specific detection antibodies and custom stable cell lines for epithelial tumor research.
CADM1 proteins are validated via homotypic cell-cell adhesion and Dlg scaffold co-binding functional testing.
