Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CC motif chemokine ligand 24 (CCL24), also known as eotaxin-2, is a soluble secreted CC chemokine encoded by the CCL24 gene and produced by several stromal and myeloid cell populations. After secretion into the extracellular microenvironment, CCL24 acts as a chemotactic ligand rather than a membrane-embedded receptor and therefore contains no transmembrane segment or intracellular signaling domain. Its principal chemotactic receptor is CCR3, a G protein-coupled receptor highly expressed on eosinophils and also present on several other immune and stromal cell types. Binding of CCL24 to CCR3 activates receptor-dependent intracellular signaling and promotes eosinophil migration toward sites where CCL24 concentrations are elevated. CCL24 can also contribute to activation-related responses in CCR3-expressing cells. Through the formation of extracellular chemokine gradients, locally produced CCL24 participates in the recruitment and positioning of eosinophils and other responsive cells within tissues. Changes in CCL24 production can therefore influence the magnitude and distribution of eosinophilic inflammatory responses in a tissue- and context-dependent manner.
Sequence variation within the CCL24 gene may affect protein expression or ligand-receptor interactions, although the functional consequences of individual variants require experimental validation. CCL24 belongs to the eotaxin family together with CCL11 and CCL26, all of which can promote eosinophil chemotaxis through CCR3. Changes in CCL24 expression have been associated with inflammatory conditions characterized by recruitment or activation of CCR3-expressing cells, making the chemokine useful for studies of chemokine-receptor interactions and leukocyte migration. As a secreted extracellular ligand, CCL24 establishes local concentration gradients and binds CCR3 on target cells, triggering GPCR-mediated intracellular signaling rather than acting as a passive extracellular binding molecule. CCL24-CCR3 signaling can regulate chemotaxis, cytoskeletal responses, calcium mobilization, and other activation-associated processes. Reduced or increased CCL24 availability can consequently alter eosinophil recruitment depending on the biological context, supporting the use of CCL24 as a research target for studies of CC chemokine signaling, eosinophil biology, and inflammatory cell trafficking.
Fig. 1 Schematic of CCL24‑mediated eosinophil chemotaxis. Soluble secreted CCL24 engages cell‑surface CCR3 receptors on eosinophils to drive granulocyte migratory responses.1
The biological functions of soluble CCL24 chemokine protein are centered on CCR3 engagement, GPCR signaling, and eosinophil-directed chemotaxis:
Creative Biolabs offers purified CCL24 protein samples produced under unified preparation workflows, including full-length CCL24 constructs and isolated receptor-binding domain variants. Truncated domain fragments cannot support complete receptor-engagement behaviors, while full-length constructs suit research focused on chemokine-receptor association and granulocyte chemotaxis observation. All batches receive uniform quality screening. Functional relevant observation may only be carried out with full-length samples under simulated extracellular microenvironment setups. Consistent structural features are preserved across batches to support comparative laboratory analysis across separate test groups. Full-length CCL24 samples retain intact receptor-binding motif conformation after standardized purification, which supports reliable detection of weak and transient ligand-receptor contacts for comparative functional analysis.
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Creative Biolabs provides adjustable CCL24 expression cell research models with varied expression levels, applicable to structural observation of soluble CC-chemokines and research into receptor-ligand molecular interaction. Sample evaluation includes sustained target expression detection and preliminary receptor-interaction observation, enabling side-by-side comparison of ligand-binding behaviors under differing expression abundances. These cell systems can pair with diverse laboratory analysis schemes to track changes in receptor-engagement efficiency alongside shifting target protein levels.
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Anti-CCL24 recombinant antibodies are generated via standardized protein preparation workflows, compatible with routine laboratory detection techniques for extracellular localization mapping and identification of ligand-receptor molecular complexes. The antibody series can work alongside common laboratory detection reagents to realize multi-dimensional observation of target distribution within immune-related tissue samples.
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Beyond catalog products, Creative Biolabs offers specialized custom services for CCL24 research:
CCL24 is a soluble secreted CC chemokine that binds CCR3 and promotes eosinophil chemotaxis through receptor-dependent GPCR signaling.
CCL24 expression can influence CCR3-mediated eosinophil recruitment and inflammatory cell trafficking, making it a useful research target for chemokine-receptor signaling and eosinophil biology.
No, all CCL24 related products and services are strictly for research use only, and cannot be applied in clinical workflows. All material designs and functional tests are optimized exclusively for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full-length CCL24 soluble protein, target-specific recombinant antibodies and tunable expression cell research models, supporting research on CCL24-CCR3 signaling and eosinophil recruitment.
Laboratory observation schemes may include ligand-receptor interaction related tests to analyze molecular-binding associated behaviors under simulated extracellular environments.
