Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CD101 molecule is a single-pass transmembrane immunoregulatory glycoprotein encoded by CD101 gene, predominantly expressed within suppressive myeloid immune cell populations including regulatory macrophages and dendritic cell subsets, localized exclusively to cell surface lipid bilayers. Distinct from other immunoglobulin superfamily surface molecules, CD101 relies on multiple conserved extracellular glycosylated domains to mediate intercellular receptor-ligand contact, while simultaneously controlling the transmission of intracellular immune-suppressive signals to constrain excessive inflammatory cascades. Under resting physiological immune states, basal CD101 surface expression sustains stable immune tissue tolerance without complete silencing of innate immune surveillance. Upon sustained inflammatory stimulation, accumulated CD101 intercellular complexes deliver inhibitory signaling to limit overactive myeloid effector function, restraining excessive pro-inflammatory mediator release. Unlike broad-spectrum inhibitory surface molecules with general immune dampening roles, CD101 bears myeloid-specific suppressive regulatory functions that cannot be fully compensated by other tolerance-associated glycoproteins, linking cell-cell molecular contact directly to immune tolerance maintenance pathways. Loss of functional CD101 severely diminishes myeloid immune suppression capacity and exacerbates tissue inflammatory responses, while sustained high CD101 expression amplifies immune tolerance and weakens anti-pathogen immune reactivity, establishing CD101 as a core research target for regulatory membrane glycoprotein biology and immune modulatory compound exploration.
CD101 executes core intercellular inhibitory signaling function embedded within cell surface lipid bilayers, utilizing tandem glycosylated extracellular domains to mediate stable homotypic and heterotypic cell-surface molecular interactions. Conserved extracellular recognition domains exclusively bind complementary cell surface counter-receptors, separating its binding spectrum from other non-tolerance immunoglobulin superfamily molecules distributed across immune cell surfaces. CD101-mediated receptor interaction bridges intercellular immune cell contact and intracellular suppressive signal transduction, balancing inflammatory response magnitude and immune tissue tolerance according to local stimulus intensity. CD101 participates in extensive physiological processes including myeloid immune tolerance maintenance, inflammatory response restriction and steady-state tissue immune equilibrium. Deficient CD101 expression disrupts inhibitory immune signal transmission and impairs systemic immune homeostasis. Therefore, CD101 represents a pivotal research target for regulatory immunoglobulin superfamily study and inflammation-limiting compound screening.
Fig. 1 Genomic locus, functional single-nucleotide variants and domain architecture of human CD101 protein.1
The biological functions of CD101 are focused on cell surface counter-receptor recognition, suppressive signal transmission and myeloid inflammatory restraint control:
Creative Biolabs offers high-quality CD101 proteins through optimized expression systems, including full-length regulatory transmembrane glycoprotein and isolated extracellular binding domain variants. These products retain native conformational characteristics and suppressive signal-inducing biological activity, suitable for cell surface receptor interaction assays and immune tolerance modulator screening. All CD101 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CD101 stable cell lines, including overexpression and blank control models. These cell lines are optimized for suppressive glycoprotein expression profiling and myeloid inhibitory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CD101 are developed via advanced antibody engineering technologies, with no cross-reactivity with other immunoglobulin superfamily regulatory glycoproteins. These antibodies are validated for plasma membrane subcellular localization detection and suppressive myeloid cell expression profiling, and can be combined with inhibitory immune receptor detection reagents to analyze complete CD101 signaling complexes in immune cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CD101 research:
CD101 is a myeloid cell surface glycoprotein that mediates intercellular receptor binding to transmit immune-suppressive signals and maintain tissue immune tolerance.
CD101 acts as a critical link between intercellular immune cell contact and myeloid inhibitory signaling, balancing tissue inflammation and systemic immune tolerance.
No, all CD101 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length CD101 regulatory glycoproteins, isoform-specific detection antibodies and custom stable cell lines for immune tolerance research.
CD101 proteins are validated via cell surface counter-receptor binding functional testing.
