Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Cadherin 6 (also known as K-cadherin) is a highly conserved type II cadherin encoded by 6(CDH6 gene, which belongs to the transmembrane adhesion core protein dependent on calcium ions, and is widely involved in vertebrate adhesion connection assembly and orderly construction of tissue morphology. CDH6 is specifically expressed in embryonic renal epithelium and various glandular epithelial tissues, and the extracellular domain contains tandem calcium ion binding repeat domains, which can mediate the specific recognition of homologous cells and stabilize intercellular junction. The protein can synergistically regulate cell adhesion strength, intracellular cytoskeleton rearrangement and downstream signal cascade reaction, and ensure the regularity of tissue structure in the process of embryonic organogenesis and postnatal tissue homeostasis maintenance. Compared with other cadherin subtypes with different tissue distribution patterns, CDH6 has unique functional advantages in the regulation of epithelial tissue spatial patterns. Under pathological conditions, abnormal expression level of CDH6 can reshape cell motility and invasion potential, and participate in the abnormal progress of many diseases.
CDH6 relies on calcium-mediated extracellular homologous binding to stabilize the intercellular junction structure, activate intracellular adhesion signal pathway synchronously, coordinate and regulate the collective migration behavior of cells, and maintain the integrity and stability of tissue structure. Its highly conserved extracellular structural motifs can accurately identify homologous cells, continuously start intracellular signal transduction, and maintain the physiological stability of epithelial tissues. CDH6 is widely involved in many basic biological processes, such as embryonic organ development, epithelial cell adhesion construction and long-term tissue homeostasis maintenance. When the expression of CDH6 is unbalanced or its function is damaged, the integrity of intercellular junction structure is destroyed and the cell invasion ability is significantly improved, which is closely related to the malignant progress of many epithelial tumors. To sum up, CDH6 is an indispensable core target in the study of cell adhesion mechanism mediated by cadherin, epithelial development physiology and molecular mechanism of tumor metastasis.
Fig. 1 Schematic diagram of CDH6-integrin crosstalk activating Src-AKT-ERK cascade to promote ovarian and renal cancer metastasis.1
The biological functions of CDH6 mainly focus on calcium ion-mediated homologous cell adhesion, epithelial morphogenesis and tumor cell migration regulation, and its core functions are as follows:
Creative Biolabs offers high-quality CDH6 proteins via optimized expression platforms, covering full-length CDH6 and isolated functional domain variants. These products retain native spatial conformation and intact calcium-dependent adhesion activity, suitable for cell adhesion interaction detection, epithelial developmental research and anti-tumor small molecule screening. All CDH6 protein batches undergo rigorous quality verification to guarantee consistent performance and reliable applicability across diverse cell biology research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CDH6 stable cell strains, including overexpression and expression-interference models. These strains are optimized for cadherin adhesion function research, epithelial signal transduction and anti-tumor compound activity assessment. Each cell strain undergoes strict functional validation to ensure steady target expression levels and uniform experimental performance across multiple research scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CDH6 are developed via advanced antibody engineering technologies. These antibodies are validated for multiple experimental applications, including target protein expression quantification, epithelial membrane localization detection, cell adhesion binding assessment and translational oncology research, enabling accurate characterization of CDH6 expression abundance, subcellular distribution and functional regulatory status under physiological and pathological contexts.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CDH6 research:
CDH6 is a type II cadherin mediating calcium-dependent homotypic cell adhesion and activating FAK/AKT oncogenic signaling to drive tumor EMT and metastasis.
CDH6 is a tumor-restricted surface marker with high internalization efficiency, serving as promising antibody-drug conjugate therapeutic target for ovarian and renal cancers.
No, all CDH6 products and services are strictly for research use only, not intended for clinical diagnosis or human therapy trials.
Offerings include full-length CDH6 glycoproteins, isoform-specific detection antibodies and custom stable cell lines for tumor adhesion research.
CDH6 proteins are validated via calcium-dependent homotypic cell adhesion binding assays.
