Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CEA cell adhesion molecule 6 (CEACAM6) is a glycosylated cell-surface immunoglobulin superfamily protein encoded by the CEACAM6 gene, enriched in epithelial and transformed tumor cell populations, anchored to plasma membrane lipid bilayers. Distinct from homeostatic CEACAM paralogs, CEACAM6 mediates homotypic intercellular crosslinking via conserved extracellular Ig domains while modulating inhibitory immune receptor engagement to dampen anti-tumor effector responses. Under normal epithelial steady states, low CEACAM expression maintains mild intercellular adhesion without immune suppression. Upon malignant transformation, elevated CEACAM6 surface abundance reinforces tumor cell clustering and blocks myeloid-mediated anti-tumor surveillance signals. Unlike constitutive epithelial adhesion factors, CEACAM6 carries tumor-specific migratory and immune-inhibitory functions that cannot be fully compensated by other CEACAM members, linking homotypic cell binding to neoplastic dissemination pathways. Loss of CEACAM6 attenuates tumor invasive capacity, while sustained overexpression accelerates metastasis and immune evasion, marking CEACAM6 as a core research target for tumor adhesion protein and anti-tumor compound screening.
CEACAM6 executes homotypic adhesion and immune modulatory function embedded in cell surface bilayers, utilizing conserved Ig-like extracellular pockets to mediate self-association and interaction with myeloid inhibitory receptors. Conserved binding motifs separate its ligand spectrum from tissue-restricted CEACAM isoforms. CEACAM6-mediated molecular bridging connects tumor cell clustering to suppressive immune signal transduction, balancing invasive potential according to malignant transformation grade. CEACAM6 participates in epithelial tissue adhesion, tumor metastatic spread and local immune suppression. Deficient CEACAM6 expression disrupts neoplastic cell aggregation and weakens immune evasion capacity. Therefore, CEACAM6 represents a pivotal research target for Ig adhesion protein and anti-metastatic compound screening.
Fig. 1 Stage-specific dual functions of CEACAM6: suppressing tumor at early phase while facilitating malignant progression at advanced phase via immune escape, migration and anti-apoptosis.1
The biological functions of CEACAM6 are focused on homotypic cell adhesion, inhibitory immune receptor binding and neoplastic migration control:
Creative Biolabs offers high-quality CEACAM6 proteins through optimized expression systems, including full-length transmembrane glycoprotein and isolated extracellular Ig domain variants. These products retain native homotypic adhesion biological activity, suitable for cell-cell interaction and anti-metastatic modulator screening. All CEACAM6 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CEACAM6 stable cell lines, including overexpression and blank control models. These cell lines are optimized for adhesion glycoprotein profiling and migratory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CEACAM6 are developed via advanced antibody engineering technologies, with no cross-reactivity with other CEACAM family glycoproteins. These antibodies are validated for plasma membrane localization detection and tumor tissue expression profiling, and can be combined with epithelial marker reagents to analyze complete intercellular adhesion complexes in tumor cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CEACAM6 research:
CEACAM6 is an Ig superfamily membrane glycoprotein mediating epithelial homotypic adhesion and regulating tumor cell migratory capacity.
CEACAM6 links epithelial cell contact to malignant invasion, acting as a key marker and effector of metastatic progression.
No, all CEACAM6 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length CEACAM6 membrane glycoproteins, isoform-specific detection antibodies and custom stable cell lines for metastasis research.
CEACAM6 proteins are validated via homotypic cell adhesion functional testing.
