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A wider family of G protein-coupled receptors includes the muscarinic cholinergic receptors. The binding of acetylcholine defines the functional diversity of these receptors, which includes physiological reactions such adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Numerous cholinergic effects on the central and peripheral nervous systems are influenced by muscarinic receptors. Although the therapeutic relevance of this receptor is unknown, animal studies have connected its action to adenylyl cyclase inhibition.
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