Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CXC motif chemokine ligand 3 (CXCL3) is a secreted inflammatory CXC chemokine encoded by the CXCL3 gene, which can be rapidly induced in epithelial cells, macrophages, and tumor-associated stromal cells under inflammatory and other microenvironmental stimuli. Like the related GRO family chemokines CXCL1 and CXCL2, CXCL3 activates CXCR2 and promotes neutrophil recruitment to inflammatory and tumor-associated tissues. In acute inflammatory responses, transient CXCL3 production contributes to neutrophil mobilization and host defense. In solid tumor microenvironments, sustained CXCL3 expression may promote recruitment of tumor-associated neutrophils and contribute to tumor-associated inflammation and immune regulation. Therefore, CXCL3 is an important research target for CXCR2-dependent neutrophil chemotaxis, inflammation, and tumor microenvironment studies.
CXCL3 is a soluble ELR-positive CXC chemokine that activates CXCR2 on myeloid cells and primarily promotes neutrophil chemotaxis. CXCL3-mediated leukocyte recruitment links inflammatory and tumor-associated signals with changes in local myeloid cell infiltration. It is involved in acute inflammatory responses and has also been associated with the progression of myeloid cell-rich solid tumors. Altered CXCL3 activity can influence neutrophil recruitment in inflammatory and tumor tissues. Overall, CXCL3 represents an important research target for studying ELR-positive CXC chemokine signaling and CXCR2-dependent myeloid cell recruitment.
Fig. 1 Liver hepatocellular carcinoma panoramic mechanistic schematic illustrating autocrine and paracrine CXCL3-CXCR2 signaling driving tumor proliferation, stromal remodeling, neutrophil recruitment and distant metastatic migration.1
The biological functions of secreted ELR-motif CXCL3 chemokine are fully focused on high-affinity CXCR2 receptor binding and myeloid inflammatory signal amplification:
Creative Biolabs offers high-quality CXCL3 proteins through optimized eukaryotic secretion systems, including full-length mature secreted CXCL3 and isolated CXCR2-binding domain variants. These products retain native potent myeloid chemotactic activity, suitable for sepsis and tumor immune modulator screening assays. All CXCL3 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse inflammation research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CXCL3 stable cell lines, including inflammatory-inducible overexpression and blank empty vector control models. These cell lines are optimized for CXC chemokine profiling and myeloid migratory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles during long-term epithelial cell culture, and can be deployed for large-scale anti-sepsis and anti-tumor immune compound screening experiments.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CXCL3 are developed via advanced antibody engineering technologies, with no cross-reactivity with CXCL1/CXCL2 homologous chemokines. These antibodies are validated for interstitial inflammatory chemokine detection and tumor stromal tissue expression profiling, and can be combined with CXCR2 detection reagents to analyze complete CXCL3 myeloid recruitment complexes in epithelial cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CXCL3 research:
CXCL3 is an ELR+ CXC chemokine that strongly activates CXCR2 to recruit neutrophils and monocytes to inflamed or tumor tissue.
CXCL3 drives acute sepsis organ injury and tumor myeloid immune suppression, dual inflammatory oncology target.
No, all CXCL3 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length mature CXCL3 chemokines, isoform-specific detection antibodies and custom stable cell lines for myeloid inflammation research.
CXCL3 proteins are validated via CXCR2 binding and neutrophil chemotaxis functional testing.
