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CXCL8

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Interleukin 8 (IL-8) or CXCL8 is a non-glycosylated protein of 8 kDa belonging to the CXC family of chemokines. IL-8 is produced as a precursor protein of 99 amino acids and processing of the precursor results in variants of IL-8 that have various biological effects. It is produced by a number of cell types in response to inflammatory stimuli such as LPS, TNF and viruses. The IL-8 receptor belongs to the G-protein coupled receptor family and is expressed on many cell types including neutrophilic granulocytes. The role of IL-8 is primarily to attract neutrophilic granulocytes to the site of inflammation upon binding to the receptor. IL-8 causes a transient increase in cytosolic calcium levels, the release of enzymes from granules as well as enhanced expression of adhesion molecules in neutrophils.
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