Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Atypical chemokine receptor 3 (CXCR7) is a seven pass transmembrane G‑protein‑coupled‑like receptor encoded by CXCR7 gene. This protein localizes mainly to plasma membrane and also occurs on intracellular vesicle membranes in several cell populations. CXCR7 contains seven transmembrane helices embedded in lipid bilayer, with extracellular N terminal region and intracellular C terminal cytoplasmic tail. Extracellular loops together with N terminal segment form chemokine ligand binding surfaces. Polypeptide folds inside endoplasmic reticulum before trafficking to cell surface or endosomal compartments. Unlike classic chemokine GPCR members, CXCR7 lacks key sequence motifs required for canonical G‑protein coupling. Different cell types exhibit distinct CXCR7 expression magnitude, and protein distribution balances between cell surface and intracellular vesicle pools. Proper helix packing is required to form functional ligand binding pockets.
CXCR7 binds selected chemokine ligand molecules at cell surface. After ligand engagement, the receptor‑ligand complex frequently undergoes endocytic internalization into intracellular vesicle compartments. Within endosomal compartments, ligand may dissociate from receptor protein. Receptor molecules can recycle back toward plasma membrane for new rounds of ligand capture. CXCR7 does not trigger classic G‑protein‑dependent downstream signal cascades upon ligand binding. Other chemokine receptors possess different ligand preference and downstream coupling profiles and cannot fully replace CXCR7 function. Variation in CXCR7 abundance changes total cellular capacity for chemokine ligand sequestration and endocytic turnover. Sequence alteration within extracellular binding surfaces impairs chemokine recognition. Mutation of cytoplasmic tail motifs disturbs endocytosis or receptor recycling dynamics without abolishing ligand binding capability.
Fig. 1 Intracellular structural features of human atypical chemokine receptor ACKR3 (CXCR7). Trans‑membrane helices and intracellular loop regions are displayed, highlighting structural characteristics relevant to G‑protein coupling incompetence.1
The biological functions of CXCR7 are focused on chemokine ligand molecular capture, receptor‑ligand complex endocytosis and vesicle‑driven receptor recycling:
Creative Biolabs offers purified CXCR7 membrane samples via standardized preparation workflows, including full length CXCR7 constructs and isolated extracellular domain variants. Isolated extracellular fragments may not support complete chemokine capture and endocytic trafficking related behaviours, while full length constructs may be suited for atypical chemokine receptor ligand‑binding‑associated research. All samples receive routine quality screening, and functional relevant observation may only be carried out with full length samples under simulated membrane environments. All sample batches follow unified processing standards to maintain consistent structural features for comparative laboratory analysis across separate test groups.
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Creative Biolabs provides adjustable CXCR7 expression cell models with varied expression levels, applicable to seven‑pass atypical chemokine receptor structural characteristic observation and chemokine ligand binding related research. Sample evaluation includes sustained target expression detection and preliminary intermolecular interaction associated observation, which can support comparative analysis of receptor associated behaviours under different expression statuses. These cell systems can be matched with diverse laboratory analysis schemes to observe changes of ligand recognition efficiency under different target expression abundances.
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Antibody reagents targeting CXCR7 are generated via mature protein preparation workflows, compatible with multiple routine laboratory detection methods for cellular localization profiling and molecular complex identification, to support systematic analysis of CXCR7 distribution and chemokine receptor associated molecular complexes across diverse laboratory research setups. The antibody series can cooperate with other common laboratory detection reagents to complete multi dimensional observation of target distribution inside tissue samples.
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Beyond catalog products, Creative Biolabs offers specialized custom services for CXCR7 research:
CXCR7 may function as atypical seven‑transmembrane chemokine receptor and participate in selective chemokine ligand capture together with endocytic internalization and receptor recycling.
CXCR7 expression status may influence cellular chemokine sequestration capacity, serving as a major regulatory mediator of atypical chemokine receptor related biological processes.
No, all CXCR7 related products and services are strictly for research use only, not intended for clinical related operations. All material designs and functional tests are only optimized for basic laboratory research scenarios, without matching clinical application standards.
Offerings include full length CXCR7 membrane protein, target specific recombinant antibodies and adjustable expression cell research models, supporting atypical chemokine receptor ligand binding research.
Laboratory observation schemes may include chemokine receptor ligand‑binding related tests to analyse receptor associated behaviours under simulated cellular environments.
