Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
The CYP2C9 gene is located on human chromosome 10q24 and encodes the CYP2C9 enzyme, a member of the cytochrome P450 superfamily. CYP2C9 is a single-chain heme protein with a molecular weight of approximately 55 kDa and is mainly expressed in the liver and intestine. As an important phase I drug-metabolizing enzyme, CYP2C9 catalyzes the oxidative metabolism of approximately 15% of commonly used drugs, including anticoagulants such as warfarin, anticonvulsants such as phenytoin, hypoglycemic drugs such as tolbutamide, and various non-steroidal anti-inflammatory drugs such as diclofenac and ibuprofen. The CYP2C9 gene is highly polymorphic, and the most common reduced-function variants include CYP2C92 and CYP2C93. These variants can decrease enzyme activity and alter substrate metabolism and drug clearance to different extents. Differences in CYP2C9 activity are therefore widely studied to understand substrate recognition, catalytic function, and the effects of genetic variation on xenobiotic metabolism. CYP2C9 also serves as an important research model for investigating cytochrome P450-mediated oxidation and interindividual variability in drug metabolism.
Fig. 1 CYP2C9 structure showing substrate recognition sites (SRS) according to Gotoh.1
The functions of CYP2C9 are mainly manifested as follows:
Creative Biolabs offers high-quality CYP2C9 recombinant protein products for studies of CYP2C9 structure, function, and metabolism-related mechanisms. These products are suitable for general research applications such as protein characterization, antibody screening, binding studies, and biochemical analysis, providing useful tools for investigating CYP2C9 substrate recognition, catalytic function, and the effects of genetic variation on enzyme activity.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Developing robust cellular models is critical for CYP2C9 research. Creative Biolabs provides custom-engineered CYP2C9 membrane protein stable cell lines that reliably express high levels of target CYP2C9. These stable cell lines are ideal for drug screening, ligand binding studies, functional assays, and high-throughput screening, offering a consistent and reproducible platform for investigating CYP2C9 biology and pharmacology. Our expertise ensures optimal expression and cellular integrity, accelerating your research pipeline.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
Our comprehensive portfolio includes high-affinity recombinant antibodies targeting CYP2C9, developed to meet the rigorous demands of various research applications. These antibodies, produced using advanced recombinant technologies, offer superior specificity, sensitivity, and batch-to-batch consistency compared to traditional polyclonal antibodies. Our CYP2C9 recombinant antibodies are validated for use in Western Blotting (WB), ELISA, Flow Cytometry (FCM), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC), and Immunoprecipitation (IP), empowering accurate detection and quantification of CYP2C9 in diverse sample types.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond our catalog products, Creative Biolabs offers specialized custom services for membrane protein and antibody discovery & development. Leveraging our extensive expertise and state-of-the-art platforms, we can assist you with:
CYP2C9 is mainly involved in the metabolism of various commonly used clinical drugs, such as warfarin, phenytoin and ibuprofen, as well as the metabolism of endogenous substances like arachidonic acid. It plays a crucial role in maintaining the concentration and efficacy of drugs in the body.
CYP2C9 exhibits significant genetic polymorphism (such as 2, 3 alleles), which can lead to reduced enzyme activity, affect drug efficacy and increase the risk of adverse reactions (such as bleeding). Therefore, it is one of the core targets for individualized medication and clinical pharmacology research.
No, all Creative Biolabs' CYP2C9 products and services are strictly for research use only and are not intended for clinical diagnosis, prevention, treatment, or cure of any disease.
We offer a range of products, including recombinant CYP2C9 membrane proteins, stable cell lines expressing CYP2C9, and high-quality recombinant CYP2C9 antibodies, along with comprehensive custom services.
