Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights
Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Dihydroorotate dehydrogenase (quinone) (DHODH) is an indispensable mitochondrial inner membrane oxidoreductase encoded by the DHODH gene, belonging to the dihydroorotate dehydrogenase enzyme family and acting as the rate-limiting effector of de novo pyrimidine biosynthetic pathway and cellular proliferative regulation. DHODH is widely expressed across proliferative somatic and immune cell populations, with evolutionarily conserved quinone-binding and catalytic dehydrogenase domains across species, serving as an essential modulator for dihydroorotate oxidation, uridine monophosphate precursor generation and mitochondrial respiratory chain coordination. DHODH-mediated catalytic activity exerts decisive effects on sustaining intact nucleotide pools, genome replication and immune cell clonal expansion under physiological conditions. Furthermore, DHODH coordinates downstream signaling cascades governing cellular redox balance, inflammatory response and immune cell differentiation to safeguard intact tissue physiological function. Distinct from other metabolic enzymes with divergent substrate affinity profiles, DHODH carries unique non-redundant duties in pyrimidine precursor synthesis and immune homeostasis, rendering it indispensable for regular cell cycle progression, inflammatory signal transduction and overall tissue stress resistance.
DHODH executes biological functions through binding dihydroorotate substrates and membrane quinone cofactors to trigger redox catalysis, driving continuous pyrimidine precursor production to support sustained nucleotide synthesis during cellular proliferation, which supplies balanced nucleotide substrates throughout cellular compartments. Its conserved functional domains mediate substrate recognition and electron transfer, enabling precise tuning of pyrimidine metabolism and intracellular redox signal transmission. DHODH-dependent signaling sustains systemic cellular metabolic equilibrium, covering intact pyrimidine biosynthesis cycles, coordinated mitochondrial redox homeostasis and persistent proliferative capacity surveillance. DHODH participates in an extensive spectrum of biological processes, such as de novo nucleotide synthesis, immune cell proliferation modulation, inflammatory signal transduction and tissue immune microenvironment maintenance. Aberrant expression or functional impairment of DHODH severely disrupts nucleotide metabolism stability, disturbs immune cell expansion and elevates susceptibility to inflammatory disorders, including autoimmune arthritis, cutaneous inflammatory lesions and hematopoietic proliferative abnormalities. Therefore, DHODH constitutes a pivotal research target for investigating metabolic enzymology, immune cell physiology and inflammatory disease pathogenic mechanisms.
Fig. 1 Schematic diagram of DHODH distribution in astrocyte endfeet and the pathogenic process of neuromyelitis optica induced by DHODH-IgG autoantibody.1
The biological functions of DHODH are focused on quinone-dependent dehydrogenase catalysis, de novo pyrimidine precursor synthesis and immune proliferative regulation:
Creative Biolabs offers high-quality DHODH proteins via optimized expression systems, covering full-length DHODH and isolated functional domain variants. These products retain native spatial conformation and intrinsic dehydrogenase biological activity, suitable for pyrimidine metabolic activity analysis, enzyme-substrate interaction studies and small molecule compound screening targeting inflammatory diseases. All DHODH proteins undergo rigorous quality control to guarantee consistent functional performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered DHODH stable cell lines, including overexpression and gene silencing models. These cell line models are optimized for pyrimidine metabolism research, immune proliferative phenotype observation and compound response profiling. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting DHODH are developed with advanced antibody engineering workflows, without cross-reactivity against other dehydrogenase family homologs. These antibodies receive multi-scenario functional validation, applicable to protein expression profiling, mitochondrial membrane localization detection, enzyme-substrate binding interaction assessment and inflammatory disease research, enabling precise characterization of DHODH expression patterns, subcellular compartment distribution and functional modulation under physiological and pathological states.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for DHODH research:
DHODH is a core mitochondrial dehydrogenase enzyme that mediates quinone-dependent pyrimidine precursor synthesis, mitochondrial redox coordination and immune cell proliferative regulation.
DHODH exerts irreplaceable control over de novo nucleotide metabolism and inflammatory immune activation; its functional defects trigger persistent autoimmune inflammation, establishing it as a vital research target.
No, all DHODH products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include DHODH proteins, high-specificity recombinant antibodies and custom stable cell lines for metabolic and inflammatory disease research.
DHODH proteins undergo functional verification via dehydrogenase catalytic activity assessment, substrate binding affinity analysis and conformational stability evaluation.
