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This gene encodes a G protein-coupled receptor protein that triggers a calcium-phosphatidylinositol second messenger pathway. Three highly effective vasoactive peptides make up its ligand, endothelin, including ET1, ET2, and ET3. The endothelinB receptor (ETB receptor) is a G-protein-coupled receptor that is a part of the endothelin receptor group, which also includes ETA. They are principally found in vascular endothelial cells, where they contribute to cell proliferation, vasoconstriction, and vasodilation.
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