Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Epithelial membrane protein 1 (EMP1) is a four-pass transmembrane protein of the PMP22/EMP family encoded by the EMP1 gene and expressed in multiple epithelial tissues. EMP1 has been associated with epithelial differentiation, cell migration, and proliferation, although its functions can vary across tissue and disease contexts. Altered EMP1 expression has also been reported in several tumor models, including associations with invasive phenotypes and resistance to EGFR-pathway inhibitors. However, the underlying mechanisms appear context dependent and should not be attributed to a universal lipid raft scaffolding or sustained EGFR signaling function. Therefore, EMP1 is an important research target for epithelial membrane protein biology, tumor-associated signaling, and resistance-related research models.
EMP1 is located in the lipid bilayer of epithelial cell membrane, which mainly plays a role in the regulation of lipid raft signal microenvironment. It relies on four-segment conservative transmembrane spiral structure to reshape the micro-domain structure of cell membrane, recruit proliferation-related signal receptors, and build a continuous proliferation-promoting signal platform. Its extensive epithelial tissue distribution characteristics are significantly different from other EMP subtypes with limited functions, making it a broad-spectrum core factor for regulating epithelial cancer signals. The process of cell membrane remodeling mediated by EMP1 can link the activity of growth factor receptor with tumor invasion phenotype, and dynamically balance the process of normal epithelial renewal and malignant tumor proliferation according to the carcinogenic mutation state of cells. This protein is involved in many physiological and pathological processes, such as the re-epithelization of skin wounds, the steady-state maintenance of glioma stem cells and the progress of EGFR-resistant lung cancer. The loss of EMP1 function can destroy the assembly of tumor carcinogenesis signal complex and significantly weaken the metastatic potential of tumor cells. To sum up, EMP1 is the key research target of epithelial membrane protein mechanism analysis and tumor drug resistance targeted therapy research and development.
Fig. 1 Panoramic tumor microenvironment schematic illustrating EMP1-mediated regulation of integrin/CD44 adhesion, MMP matrix degradation, angiogenesis and malignant invasive progression of epithelial carcinoma.1
The biological functions of four-transmembrane EMP1 regulator are fully focused on membrane microdomain assembly and EGFR resistance promotion:
Creative Biolabs offers high-quality EMP1 proteins through optimized epithelial expression systems, including full-length four-transmembrane protein and isolated transmembrane domain variants. These products retain native lipid raft organizing and signaling recruitment activity, suitable for EGFR resistance and anti-metastasis compound screening assays. All EMP1 proteins undergo strict quality control to ensure consistent performance and reliable application across epithelial oncology research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered EMP1 stable cell lines, including EGFR-mutant tumor overexpression and blank empty vector control models. These cell lines are optimized for epithelial membrane protein profiling and drug resistance signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles during long-term drug-treated cell culture, and can be widely deployed for targeted therapy sensitization compound screening experiments.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting EMP1 are developed via advanced antibody engineering technologies, with no cross-reactivity with EMP2/EMP3 homologous proteins. These antibodies are validated for epithelial and tumor cell membrane localization detection and lung tissue expression profiling, and can be combined with EGFR detection reagents to analyze complete EMP1 signaling complexes in drug-resistant tumor cell models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for EMP1 research:
EMP1 is an epithelial membrane protein organizing lipid rafts to sustain oncogenic EGFR signaling and drive tumor drug resistance.
EMP1 is a key mediator of gefitinib resistance in EGFR-mutant lung cancer, a target for sensitizing combination therapy.
No, all EMP1 products and services are strictly for research use only, not intended for clinical diagnosis or human therapeutic trials.
Offerings include full-length EMP1 membrane proteins, isoform-specific detection antibodies and custom stable cell lines for epithelial tumor research.
EMP1 proteins are validated via lipid raft assembly and EGFR signal sustaining functional testing.
